Department of Medical Research, Kuang Tien General Hospital, Taichung, Taiwan.
Department of Endocrinology and Metabolism, Kuang Tien General Hospital, Taichung, Taiwan.
Front Endocrinol (Lausanne). 2023 Jan 16;13:1097270. doi: 10.3389/fendo.2022.1097270. eCollection 2022.
We investigated the associations of exposure to particulate matter with an aerodynamic diameter less than 2.5 μm (PM) and several gaseous pollutants with risk of gestational diabetes mellitus (GDM) in Taiwan.
We retrospectively identified pregnant women who underwent a two-step approach to screen for GDM between 2006 and 2014. Information on concentrations of air pollutants (including PM, sulfur dioxide [SO], nitrogen oxides [NO], and ozone [O]) were collected from a single fixed-site monitoring station. We conducted logistic regression analyses to determine the associations between exposure to air pollutants and risk of GDM.
A total of 11210 women were analyzed, and 705 were diagnosed with GDM. Exposure to PM during the second trimester was associated with a nearly 50% higher risk of GDM (odds ratio [OR] 1.47, 95% CI 0.96 to 2.24, p=0.077). The associations were consistent in the two-pollutant model (PM + SO [OR 1.73, p=0.038], PM + NO [OR 1.52, p=0.064], PM + O [OR 1.96, p=0.015]), and were more prominent in women with age <30 years and body mass index <25 kg/m (interaction p values <0.01).
Exposure to PM was associated with risk of GDM, especially in women who were younger or had a normal body mass index.
本研究旨在探讨在台湾，大气中直径小于 2.5μm 的颗粒物（PM）和几种气态污染物暴露与妊娠糖尿病（GDM）风险之间的相关性。
我们回顾性地选择了 2006 年至 2014 年间采用两步筛查法进行 GDM 筛查的孕妇。从一个固定监测站收集了空气污染物（包括 PM、二氧化硫[SO]、氮氧化物[NO]和臭氧[O]）浓度的相关信息。我们进行了逻辑回归分析，以确定暴露于空气污染物与 GDM 风险之间的关系。
共分析了 11210 名女性，其中 705 名被诊断为 GDM。与 PM 暴露相关的第二孕期 GDM 风险增加近 50%（比值比[OR]1.47，95%置信区间[CI]0.96 至 2.24，p=0.077）。在双污染物模型（PM+SO[OR 1.73，p=0.038]、PM+NO[OR 1.52，p=0.064]、PM+O[OR 1.96，p=0.015]）中，这种相关性是一致的，并且在年龄<30 岁和体重指数<25kg/m 的女性中更为明显（交互 p 值<0.01）。
PM 暴露与 GDM 风险相关，尤其是在年轻或体重指数正常的女性中。
