Shukla Sudheesh K, Patra Santanu, Das Trupti R, Kumar Dharmesh, Mishra Anshuman, Tiwari Ashutosh
Institute of Advanced Materials IAAM Gammalkilsvägen 18 Ulrika 59053 Sweden.
VBRI Innovation Centre 7/16 Kalkaji Extn New Delhi 110019 India.
View (Beijing). 2022 Jul 20:20210020. doi: 10.1002/VIW.20210020.
The pandemic respiratory disease COVID-19 has spread over the globe within a small span of time. Generally, there are two important points are being highlighted and considered towards the successful diagnosis and treatment process. The first point includes the reduction of the rate of infections and the next one is the decrease of the death rate. The major threat to public health globally progresses due to the absence of effective medication and widely accepted immunization for the COVID-19. Whereas, understanding of host susceptibility, clinical features, adaptation of COVID-19 to new environments, asymptomatic infection is difficult and challenging. Therefore, a rapid and an exact determination of pathogenic viruses play an important role in deciding treatments and preventing pandemic to save the people's lives. It is urgent to fix a standardized diagnostic approach for detecting the COVID-19. Here, this systematic review describes all the current approaches using for screening and diagnosing the COVID-19 infectious patient. The renaissance in pathogen due to host adaptability and new region, facing creates several obstacles in diagnosis, drug, and vaccine development process. The study shows that adaptation of accurate and affordable diagnostic tools based on candidate biomarkers using sensor and digital medicine technology can deliver effective diagnosis services at the mass level. Better prospects of public health management rely on diagnosis with high specificity and cost-effective manner along with multidisciplinary research, specific policy, and technology adaptation. The proposed healthcare model with defined road map represents effective prognosis system.
大流行呼吸道疾病新型冠状病毒肺炎（COVID-19）在短时间内已蔓延至全球。一般来说，在成功的诊断和治疗过程中有两个要点被重点强调和考虑。第一点包括降低感染率，另一点是降低死亡率。由于缺乏针对COVID-19的有效药物和广泛接受的免疫方法，全球公共卫生面临的主要威胁仍在加剧。然而，了解宿主易感性、临床特征、COVID-19对新环境的适应性、无症状感染既困难又具有挑战性。因此，快速准确地确定致病病毒在决定治疗方案和预防大流行以拯救人们生命方面起着重要作用。迫切需要确定一种标准化的诊断方法来检测COVID-19。在此，本系统综述描述了目前用于筛查和诊断COVID-19感染患者的所有方法。由于宿主适应性和新区域的出现，病原体的复苏在诊断、药物和疫苗开发过程中造成了一些障碍。研究表明，基于候选生物标志物采用传感器和数字医学技术的准确且经济实惠的诊断工具能够在大规模层面提供有效的诊断服务。公共卫生管理的更好前景依赖于以高特异性和具有成本效益的方式进行诊断，以及多学科研究、特定政策和技术应用。所提出的具有明确路线图的医疗保健模式代表了有效的预后系统。
