Djaja Nanny
Department of Public Health, School of Medicine, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia.
J Nutr Metab. 2022 Jul 30;2022:1876731. doi: 10.1155/2022/1876731. eCollection 2022.
A potential effect of Job's tears on metabolic diseases has been recognized. However, studies on the effect of Job's tears on lipid profile and glycated albumin (GA) are still rare. This study aimed to examine the influence of Job's tears in conjunction with probiotics on the lipid profile and GA concentration of patients with type 2 diabetes mellitus.
This double-blind 12-week study involved 60 patients with type 2 diabetes assigned randomly into two groups. The first group consumed yogurt alone (containing La5 and Bb12), while the second had yogurt with Job's tears once daily (200 ml each). Lipids and GA concentrations were measured using an enzymatic colorimetric assay. Paired and unpaired Students -test, Wilcoxon signed-rank, and Mann-Whitney test were applied. Statistical significance was set at < 0.05.
The characteristics of the groups were comparable except for baseline plasma GA (=0.012). Subjects who used Metformin were distributed equally between the groups (=0.118). Caloric intake between the groups also did not differ (=0.856). There was also no change in weight, BMI, or plasma GA. Yogurt and the mixture of Job's tears and yogurt reduced cholesterol and LDL and increased HDL (all < 0.05) within the groups. However, HDL levels in patients who had Job's tears were significantly elevated than yogurt alone (0.9 vs. 25 mg/dL, =0.029).
The combination of Job's tears and yogurt improved HDL more than yogurt alone.
薏苡仁对代谢性疾病的潜在作用已得到认可。然而，关于薏苡仁对血脂和糖化白蛋白（GA）影响的研究仍然很少。本研究旨在探讨薏苡仁联合益生菌对2型糖尿病患者血脂和GA浓度的影响。
这项为期12周的双盲研究纳入了60例2型糖尿病患者，随机分为两组。第一组仅食用酸奶（含La5和Bb12），而第二组每天食用一次含薏苡仁的酸奶（各200毫升）。采用酶比色法测定血脂和GA浓度。应用配对和非配对学生t检验、Wilcoxon符号秩检验和Mann-Whitney检验。统计学显著性设定为<0.05。
除基线血浆GA外（=0.012），两组患者的特征具有可比性。使用二甲双胍的受试者在两组间分布均衡（=0.118）。两组间的热量摄入也无差异（=0.856）。体重、BMI或血浆GA也没有变化。酸奶以及薏苡仁与酸奶的混合物在组内均降低了胆固醇和低密度脂蛋白，并升高了高密度脂蛋白（均<0.05）。然而，食用薏苡仁的患者的高密度脂蛋白水平显著高于仅食用酸奶的患者（0.9对25毫克/分升，=0.029）。
薏苡仁与酸奶的组合比单独食用酸奶更能提高高密度脂蛋白水平。
