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慢性部分脊髓切断术对猫脊髓单胺水平的不同影响。

Differential effects of chronic partial myelotomies on monoamine levels in cat spinal cord.

作者信息

Casey K L, Morrow T J, Terry L C, Craig R

出版信息

Brain Res. 1987 Apr 7;408(1-2):377-80. doi: 10.1016/0006-8993(87)90409-4.

DOI:10.1016/0006-8993(87)90409-4
PMID:3594227
Abstract

The concentrations of 5-hydroxytryptamine (5-HT), norepinephrine (NE) and dopamine (DA) were measured in samples of lumbar and cervical spinal cords from 6 cats with chronic (over 2 months) lesions of the thoracic spinal cord and from 7 unoperated cats. Lesions confined to the dorsal thoracic spinal cord significantly lowered lumbar concentrations of NE, but not 5-HT, compared with control lumbar or matched paired cervical samples. Both NE and 5-HT were significantly reduced by dorsal or ventral lesions that involved tissue ventral to the central canal. Only the largest lesion could be shown to reduce lumbar DA concentration.

摘要

在6只患有慢性(超过2个月)胸段脊髓损伤的猫以及7只未做手术的猫的腰段和颈段脊髓样本中,测量了5-羟色胺(5-HT)、去甲肾上腺素(NE)和多巴胺(DA)的浓度。与对照腰段或配对的颈段样本相比,局限于胸段脊髓背侧的损伤显著降低了腰段NE的浓度,但未降低5-HT的浓度。涉及中央管腹侧组织的背侧或腹侧损伤均使NE和5-HT显著降低。只有最大的损伤才会使腰段DA浓度降低。

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