Hall E D, McGinley P A
J Neurochem. 1982 Jun;38(6):1787-90. doi: 10.1111/j.1471-4159.1982.tb06667.x.
The effects of a single large intravenous dose of methylprednisolone on the steady state levels of dopamine, norepinephrine, and 5-hydroxytryptamine in cat lumbar spinal cord, as a function of dose (15, 30, or 90 mg/kg) and time (1 or 24 h) after administration, were examined by high performance liquid chromatography with electrochemical detection. Methylprednisolone produced a dose-related increase in the levels of dopamine and 5-hydroxytryptamine, but not norepinephrine, measured at 1 h. The effect of the single glucocorticoid dose was biphasic, however, as measurement of the three amines at 24 h showed each to be depressed below the levels found in untreated animals. The possible mechanistic basic and the significance of these glucocorticoid effects are discussed.
通过高效液相色谱电化学检测法，研究了静脉注射单次大剂量甲基强的松龙对猫腰脊髓中多巴胺、去甲肾上腺素和5-羟色胺稳态水平的影响，该影响是给药剂量（15、30或90mg/kg）和给药后时间（1或24小时）的函数。在给药1小时时测定发现，甲基强的松龙使多巴胺和5-羟色胺水平呈剂量相关增加，但对去甲肾上腺素水平无影响。然而，单次糖皮质激素剂量的作用是双相的，因为在24小时时对这三种胺类的测量显示，每种胺类均低于未治疗动物的水平。讨论了这些糖皮质激素作用可能的机制基础及其意义。
