Fishman R H, Pleet A B, Melamed E, Abramsky O
Brain Res. 1987 May 5;410(2):343-6. doi: 10.1016/0006-8993(87)90335-0.
The significant regional variation in brain superoxide dismutase (SOD) activity was similar in mice from both warm and cool cohorts. Mice in the cool cohort generally had higher SOD activity, which varied significantly with body temperature in striatum and in preoptic area of the hypothalamus. Changes in SOD activity following heating were revealed only when warm and cool cohorts were analysed separately. SOD activity decreased significantly in striatum, hypothalamus, and hippocampus of the cool cohort only. The decline was to levels consistent with those of the warm cohort. Body temperature of cool mice increased more than that of warm mice following each increment of heating so resultant body temperatures became similar. The role of SOD as part of a differential defense against heat stress in warm and cool mice is presented.
在来自温暖组和凉爽组的小鼠中，大脑超氧化物歧化酶（SOD）活性的显著区域差异相似。凉爽组的小鼠通常具有较高的SOD活性，其在纹状体和下丘脑视前区随体温有显著变化。仅在分别分析温暖组和凉爽组时，才揭示了加热后SOD活性的变化。仅在凉爽组的纹状体、下丘脑和海马体中，SOD活性显著下降。下降后的水平与温暖组一致。在每次加热增量后，凉爽小鼠的体温升高幅度大于温暖小鼠，因此最终体温变得相似。本文阐述了SOD在温暖和凉爽小鼠中作为对抗热应激的差异防御一部分的作用。
