低维生素D水平和维生素D受体变异是乳腺癌的危险因素：一项更新的荟萃分析。

Lower vitamin D levels and VDR variants are risk factors for breast cancer: an updated meta-analysis.

作者信息

Zhao Zhenyu, Cai Wenyu, Xing Jing, Zhao Chenhui

机构信息

Department of Oncology, The Third People's Hospital of Hubei Province, (Affiliated Hospital of Jianghan University, Wuhan City, Hubei Province, China.

Department of General Surgery, Huashan hospital affiliated to Fudan University, Shanghai city, China.

出版信息

Nucleosides Nucleotides Nucleic Acids. 2023;42(1):17-37. doi: 10.1080/15257770.2022.2107217. Epub 2022 Aug 9.

DOI:10.1080/15257770.2022.2107217

PMID:35942872

Abstract

Inadequate vitamin D levels and vitamin D variants have been shown to be associated with breast cancer (BC), however the results are inconsistent. To reach a definitive conclusion the present meta-analysis was conducted. When compared to healthy controls, BC patients had reduced vitamin D levels (standard difference in means = -0.564, = 0.003). The meta-analysis revealed that the mutation was linked with an increased BC susceptibility (CC vs. TT: = 1.107, = 0.001, CC vs. TC + TT: = 1.114, = 0.020). There was no role of other VDR variants (, , and ). mutation and diminished vitamin D increase the likelihood of developing BC.

摘要

维生素D水平不足和维生素D变体已被证明与乳腺癌（BC）有关，然而结果并不一致。为得出明确结论，进行了本荟萃分析。与健康对照相比，乳腺癌患者的维生素D水平降低（平均标准差=-0.564，P=0.003）。荟萃分析显示，该突变与乳腺癌易感性增加有关（CC与TT相比：OR=1.107，P=0.001，CC与TC+TT相比：OR=1.114，P=0.020）。其他维生素D受体变体（、和）没有作用。该突变和维生素D减少增加了患乳腺癌的可能性。