Barraco R A, Phillis J W, Stair R E, Campbell W R, Shehin S E
Can J Cardiol. 1987 May;3(4):205-9.
Mice implanted with chronic indwelling cannulae were injected into the lateral cerebral ventricle with two adenosine analogs, NECA and L-PIA, and the effects on blood pressure and heart rate recorded. Both analogs produced dose-related reductions in blood pressure and heart rate. NECA exhibited approximately 10 fold more potency than L-PIA on mean arterial blood pressure. The effects of both drugs on blood pressure and heart rate were antagonized by parenteral injections of caffeine. These results show that injections of adenosine analogs into the lateral ventricle of mice can influence the areas of the central nervous system involved in the control of cardiovascular function.
给植入慢性留置套管的小鼠侧脑室注射两种腺苷类似物NECA和L-PIA，并记录对血压和心率的影响。两种类似物均产生与剂量相关的血压和心率降低。NECA在平均动脉血压上的效力比L-PIA高约10倍。两种药物对血压和心率的作用都被注射咖啡因所拮抗。这些结果表明，向小鼠侧脑室注射腺苷类似物可影响参与心血管功能控制的中枢神经系统区域。
