Barraco R A, Aggarwal A K, Phillis J W, Moron M A, Wu P H
Neurosci Lett. 1984 Jul 27;48(2):139-44. doi: 10.1016/0304-3940(84)90009-0.
Rats implanted with chronic indwelling cannulae were injected in the lateral cerebral ventricle with two adenosine analogues and the effects on spontaneous locomotor activity and blood pressure recorded. Both analogues produced dose-related decreases in locomotor activity, with 5'-N-ethylcarboxamidoadenosine (NECA) exhibiting slightly more potent depressant activity than (-)-N-(1-methyl-2-phenylethyl)adenosine (L-phenylisopropyladenosine) (L-PIA). NECA and L-PIA also produced dose-related reductions in blood pressure but the threshold dose for hypotensive activity was 10-100-fold higher than the dose required for depression of spontaneous locomotor activity. The depression of locomotor activity and the hypotensive effect of both analogues were antagonized by parenteral injections of caffeine. These results show that the hypoactive and hypotensive effects of adenosine analogues can be dissociated and that methylxanthines probably exert an antagonism of central adenosine receptors in the rat.
给植入慢性留置套管的大鼠侧脑室注射两种腺苷类似物，并记录其对自发运动活动和血压的影响。两种类似物均使运动活动呈剂量依赖性降低，其中5'-N-乙基甲酰胺基腺苷（NECA）的抑制活性略强于（-）-N-（1-甲基-2-苯乙基）腺苷（L-苯异丙基腺苷）（L-PIA）。NECA和L-PIA也使血压呈剂量依赖性降低，但降压活性的阈剂量比抑制自发运动活动所需剂量高10至100倍。腹腔注射咖啡因可拮抗两种类似物对运动活动的抑制作用和降压作用。这些结果表明，腺苷类似物的活动减退和降压作用可以分离，甲基黄嘌呤可能对大鼠中枢腺苷受体起拮抗作用。
