新生儿脑内近红外光散射与水弥散。

Near-infrared light scattering and water diffusion in newborn brains.

机构信息

Center for Human Development and Family Science, Department of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, 467-8601, Japan.

Department of Paediatrics and Child Health, Centre for Developmental and Cognitive Neuroscience, Kurume University School of Medicine, Kurume, Fukuoka, 830-0011, Japan.

出版信息

Ann Clin Transl Neurol. 2022 Sep;9(9):1417-1427. doi: 10.1002/acn3.51641. Epub 2022 Aug 9.

DOI:10.1002/acn3.51641

PMID:35943446

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9463954/

Abstract

OBJECTIVE

MRI provides useful information regarding brain maturation and injury in newborn infants. However, MRI studies are generally restricted during acute phase, resulting in uncertainty around upstream clinical events responsible for subtle cerebral injuries. Time-resolved near-infrared spectroscopy non-invasively provides the reduced scattering coefficient ( ), which theoretically reflects tissue structural complexity. This study aimed to test whether values of the newborn head reflected MRI findings.

METHODS

Between June 2009 and January 2015, 77 hospitalised newborn infants (31.7 ± 3.8 weeks gestation) were assessed at 38.8 ± 1.3 weeks post-conceptional age. Associations of values with MRI scores, mean diffusivity and fractional anisotropy were assessed.

RESULTS

Univariable analysis showed that values were associated with gestational week (p = 0.035; regression coefficient [B], 0.065; 95% confidence interval [CI], 0.005-0.125), fractional anisotropy in the cortical grey matter (p = 0.020; B, -5.994; 95%CI, -11.032 to -0.957), average diffusivity in the cortical grey matter (p < 0.001; B, -4.728; 95%CI, -7.063 to -2.394) and subcortical white matter (p = 0.001; B, -2.071; 95%CI, -3.311 to -0.832), subarachnoid space (p < 0.001; B, -0.289; 95%CI, -0.376 to -0.201) and absence of brain abnormality (p = 0.042; B, -0.422; 95%CI, -0.829 to -0.015). The multivariable model to explain values comprised average diffusivity in the subcortical white matter (p < 0.001; B, -2.066; 95%CI, -3.200 to -0.932), subarachnoid space (p < 0.001; B, -0.314; 95%CI, -0.412 to -0.216) and absence of brain abnormality (p = 0.021; B, -0.400; 95%CI, -0.739 to -0.061).

INTERPRETATION

Light scattering was associated with brain structure indicated by MRI-assessed brain abnormality and diffusion-tensor-imaging-assessed water diffusivity. When serially assessed in a larger population, values might help identify covert clinical events responsible for subtle cerebral injury.

摘要

目的

MRI 可提供有关新生儿大脑成熟和损伤的有用信息。然而，MRI 研究通常在急性期受到限制，导致对导致轻微脑损伤的上游临床事件存在不确定性。时分辨近红外光谱非侵入性地提供了减少散射系数（），理论上反映了组织结构的复杂性。本研究旨在测试新生儿头部的值是否反映了 MRI 结果。

方法

2009 年 6 月至 2015 年 1 月，在妊娠后 38.8±1.3 周时评估了 77 名住院新生儿（31.7±3.8 周胎龄）。评估了值与 MRI 评分、平均扩散率和各向异性分数之间的相关性。

结果

单变量分析表明，值与胎龄相关（p=0.035；回归系数 [B]，0.065；95%置信区间 [CI]，0.005-0.125），皮质灰质的各向异性分数（p=0.020；B，-5.994；95%CI，-11.032 至-0.957）、皮质灰质的平均扩散率（p<0.001；B，-4.728；95%CI，-7.063 至-2.394）和皮质下白质（p=0.001；B，-2.071；95%CI，-3.311 至-0.832）、蛛网膜下腔（p<0.001；B，-0.289；95%CI，-0.376 至-0.201）和无脑异常（p=0.042；B，-0.422；95%CI，-0.829 至-0.015）。解释值的多变量模型包括皮质下白质的平均扩散率（p<0.001；B，-2.066；95%CI，-3.200 至-0.932）、蛛网膜下腔（p<0.001；B，-0.314；95%CI，-0.412 至-0.216）和无脑异常（p=0.021；B，-0.400；95%CI，-0.739 至-0.061）。