Mehta R, Silinskas K C, Zucker P F, Ronen A, Heddle J A, Archer M C
Cancer Lett. 1987 Jun;35(3):313-20. doi: 10.1016/0304-3835(87)90133-9.
The rat hepatocarcinogen nitrosodimethylamine and the esophageal carcinogens nitrosomethylbenzylamine and nitrosomethylamylamine were shown to produce chromosomal damage, as manifested by micronucleus formation, in their target tissues. There was cross-reactivity in the two tissues, however, at high dose levels. Nitrosodiethylamine, which produces tumors in both the liver and esophagus in the rat, also produced micronuclei in both tissues.
