预防性抗真菌治疗期间模拟念珠菌血症检测的比较。

Comparison of simulated candidemia detection during prophylactic antifungal therapy.

机构信息

Department of Laboratory Medicine, Chung-Ang University College of Medicine, Seoul, Republic of Korea.

Department of Urology, Chung-Ang University College of Medicine, Seoul, Republic of Korea.

出版信息

Diagn Microbiol Infect Dis. 2022 Oct;104(2):115768. doi: 10.1016/j.diagmicrobio.2022.115768. Epub 2022 Jul 16.

DOI:10.1016/j.diagmicrobio.2022.115768

PMID:35944341

Abstract

BACKGROUND

We investigated the neutralization performance of various automated blood culture systems for antifungal agents with regard to the most commonly isolated Candida species.

METHODS

In this study, we evaluated the time to detection (TTD) of simulated candidemia for 6 Candida spp. (C. albicans, C. auris, C. glabrata, C. krusei, C. parapsilosis, and C. tropicalis) in 3 automated blood culture systems (BACTEC™ FX, BACT/ALERT® 3D, and BACT/ALERT® VIRTUO®), with or without trough and peak levels of eight antifungal agents (amphotericin B, anidulafungin, caspofungin, fluconazole, itraconazole, micafungin, posaconazole, and voriconazole).

RESULTS

Caspofungin and micafungin significantly prolonged the TTDs for most of the tested strains in the 3 blood culture instruments, especially at peak concentrations.

CONCLUSION

Peak concentrations of caspofungin and micafungin influence the performance of blood culture detection systems. Therefore, one should be careful about the possibility of prolonged TTDs for candidemia when using the abovementioned antifungal agents.

摘要

背景

我们研究了各种自动化血液培养系统对最常见分离的念珠菌属物种的抗真菌药物的中和性能。

方法

在这项研究中，我们评估了 6 种念珠菌属（白色念珠菌、耳念珠菌、光滑念珠菌、克柔念珠菌、近平滑念珠菌和热带念珠菌）在 3 种自动化血液培养系统（BACTEC™ FX、BACT/ALERT® 3D 和 BACT/ALERT® VIRTUO®）中模拟念珠菌血症的检测时间（TTD），其中包括或不包括 8 种抗真菌药物（两性霉素 B、阿尼芬净、卡泊芬净、氟康唑、伊曲康唑、米卡芬净、泊沙康唑和伏立康唑）的谷值和峰值水平。