儿童神经结节病：病例、影像学表现和治疗的系统综述总结。
Neurosarcoidosis in children: A systematic review and summary of cases, imaging and management.
机构信息
Lincoln Memorial University-DeBusk College of Osteopathic Medicine; 6965 Cumberland Gap Pkwy, Harrogate, TN 37752, USA.
Emory University School of Medicine, Departments of Radiology and Imaging Sciences & Pediatrics, and Children's Healthcare of Atlanta, Department of Radiology, 1405 Clifton Road NE, Atlanta, GA, USA.
出版信息
J Neuroimmunol. 2022 Oct 15;371:577938. doi: 10.1016/j.jneuroim.2022.577938. Epub 2022 Aug 1.
Neurosarcoidosis is a rare disorder in children. We identified 30 pediatric NS cases through a systematic review. Twenty-one (70%) had systemic sarcoidosis with 30% having primary neurosarcoidosis. Eyes (37%), lymph nodes (37%) and lungs (30%) were most commonly involved. Isolated neurosarcoidosis were more likely in children (30%) than in adults (6%, p = 0.0005). Seizures and optic neuritis were also more common in children than adults (33% vs 14%, p = 0.002; and 30% versus 6%, p = 0.008, respectively). Evaluation, imaging, laboratory findings, and treatments are discussed. Additional research, including multi-center studies, is needed.
神经结节病在儿童中较为罕见。我们通过系统回顾确定了 30 例儿科 NS 病例。21 例（70%）存在系统性结节病，其中 30%存在原发性神经结节病。眼睛（37%）、淋巴结（37%）和肺部（30%）最常受累。孤立性神经结节病在儿童中比在成人中更常见（30%比 6%，p=0.0005）。儿童的癫痫发作和视神经炎也比成人更常见（33%比 14%，p=0.002；30%比 6%，p=0.008）。讨论了评估、影像学、实验室发现和治疗。需要开展更多的研究，包括多中心研究。
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