National Heart and Lung Institute, Imperial College London, London, UK
PELyon, Pharmaco Epidemiologie Lyon, Lyon, France.
BMJ Open Respir Res. 2022 Aug;9(1). doi: 10.1136/bmjresp-2021-001150.
Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality in Europe; however, it is important to understand how clinical practice patterns differ between countries and how this might relate to disease outcomes, to identify ways of improving local disease management. We aimed to describe and compare the management of patients with COPD in the UK and France between 2008 and 2017.
We used data from the Clinical Practice Research Datalink GOLD and Hospital Episode Statistics in the UK and the Echantillon Généraliste des Bénéficiaire in France to identify patients with COPD each year between 2008 and 2017. We compared patient characteristics, all-cause mortality and COPD exacerbations each year between 2008 and 2017 for patients in the UK and France separately. Health care utilisation and COPD exacerbations in 2017 were compared between France and the UK using t-tests and χ tests.
Patients with COPD were similar in gender and comorbidities in both countries. Incidence of COPD exacerbations remained stable in the UK and France between 2007 and 2017. In 2017, the proportion of all-cause and COPD-related hospitalisations was greater in the UK than in France (43.9% vs 32.8% and 8.3% vs 4.9%, respectively; p<0.001) as was the proportion of patients visiting accident and emergency (A&E) (39.8% vs 16.2%, respectively; p<0.001). In addition, the mean length of stay in hospital for COPD-related causes was shorter in the UK than in France (6.2 days (SD 8.4) vs 10.5 days (SD 9.1), respectively; p<0.001).
Overall, UK patients were more likely to go to A&E, be hospitalised for COPD-related causes and stay in hospital for fewer days after being admitted for COPD-related reasons compared with patients in France, illustrating a difference in health-seeking behaviours and access to healthcare.
慢性阻塞性肺疾病(COPD)是欧洲主要的死亡原因;然而,了解各国之间的临床实践模式如何不同,以及这如何与疾病结果相关,以确定改善当地疾病管理的方法非常重要。我们旨在描述和比较 2008 年至 2017 年间英国和法国 COPD 患者的管理情况。
我们使用英国临床实践研究数据链接 GOLD 和医院发病统计数据以及法国 Echantillon Généraliste des Bénéficiaire 中的数据,每年在 2008 年至 2017 年间识别 COPD 患者。我们分别比较了 2008 年至 2017 年间英国和法国患者的患者特征、全因死亡率和 COPD 加重情况。使用 t 检验和 χ 检验比较了 2017 年法国和英国之间的医疗保健利用情况和 COPD 加重情况。
两国 COPD 患者的性别和合并症相似。2007 年至 2017 年间,COPD 加重的发生率在英国和法国保持稳定。2017 年,全因和 COPD 相关住院的比例在英国高于法国(分别为 43.9%比 32.8%和 8.3%比 4.9%;p<0.001),因 COPD 就诊急诊(A&E)的患者比例也更高(分别为 39.8%比 16.2%;p<0.001)。此外,英国 COPD 相关原因住院的平均住院时间短于法国(分别为 6.2 天(SD 8.4)比 10.5 天(SD 9.1);p<0.001)。
总体而言,与法国患者相比,英国患者因 COPD 相关原因就诊 A&E、因 COPD 相关原因住院以及住院时间较短,表明在寻求医疗保健和获得医疗保健方面存在差异。