Department of Urology, The Second Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China.
Anhui Province Key Laboratory of Translational Cancer Research, Bengbu Medical University, Bengbu, 233030, Anhui, China.
World J Surg Oncol. 2022 Aug 9;20(1):255. doi: 10.1186/s12957-022-02715-x.
Whether cytoreductive prostatectomy (CRP) should be performed in patients with oligometastatic prostate cancer (OPC) remains controversial. The goal of this systematic meta-analysis was to assess the efficacy of CRP as a treatment for OPC.
This systematic review and meta-analysis was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis statement. Data sources included publications in the PubMed, Embase, the Cochrane Library, EBSCO, and Web of Science (SCI) databases as of May 2022. Eligible articles included prospective studies comparing the efficacy of CRP to a lack of CRP in patients with OPC.
In total, 10 publications incorporating 888 patients were analyzed. Tumor-reducing prostatectomy was found to have no significant effect on long-term or short-term OS [OR = 2.26, 95% CI (0.97, 5.28), P = 0.06] and [OR = 1.73, 95% CI (0.83, 3.58), P = 0.14], but it significantly improved patient long-term or short-term CSS [OR = 1.77, 95% CI (1.01, 310), P = 0.04] and [OR = 2.71, 95% CI (1.72, 4.29), P < 0.0001] and PFS [OR = 1.93, 95% CI (1.25, 2.97), P = 0.003].
These results suggest that cytoreductive prostatectomy can confer survival benefits to OPC patients.
INPLASY protocol 202260017 https://doi.org/10.37766/inplasy2022.6.0017 .
去势前列腺切除术（CRP）是否应在寡转移性前列腺癌（OPC）患者中进行仍存在争议。本系统综述的目的是评估 CRP 作为 OPC 治疗方法的疗效。
本系统综述和荟萃分析按照系统评价和荟萃分析的首选报告项目进行。数据来源包括截至 2022 年 5 月在 PubMed、Embase、Cochrane 图书馆、EBSCO 和 Web of Science（SCI）数据库中发表的出版物。合格的文章包括比较 CRP 与 OPC 患者缺乏 CRP 的疗效的前瞻性研究。
共分析了 10 项纳入 888 名患者的研究。肿瘤缩小性前列腺切除术对长期或短期 OS 没有显著影响[OR=2.26，95%CI（0.97，5.28），P=0.06]和[OR=1.73，95%CI（0.83，3.58），P=0.14]，但显著改善了患者的长期或短期 CSS[OR=1.77，95%CI（1.01，310），P=0.04]和[OR=2.71，95%CI（1.72，4.29），P<0.0001]和 PFS[OR=1.93，95%CI（1.25，2.97），P=0.003]。
这些结果表明，去势前列腺切除术可以为 OPC 患者带来生存获益。
INPLASY 方案 202260017 https://doi.org/10.37766/inplasy2022.6.0017 。
