Shu Long, Yu Dan, Jin Fubi
Department of Nutrition, Zhejiang Hospital, Xihu District, Hangzhou, Zhejiang, the People's Republic of China.
Department of Endocrinology, Zhejiang Hospital, Hangzhou, Zhejiang310013, the People's Republic of China.
Br J Nutr. 2022 Aug 10:1-9. doi: 10.1017/S0007114522002598.
The association between alcohol intake and the risk of glioma has been widely studied, but these results have yielded conflicting findings. Therefore, we conducted this systematic review and updated meta-analysis to systematically evaluate the association between alcohol intake and the risk of glioma. A systematic literature search of relevant articles published in PubMed, Web of Science, CNKI and Wan fang databases up to December 2021 was conducted. Pooled estimated of relative risk (RR) and 95 % CI were calculated using fixed-effects models. A total of eight articles with three case-control studies involving 2706 glioma cases and 2 189 927 participants were included in this meta-analysis. A reduced risk of glioma was shown for the low-moderate alcohol drinking . non-drinking (RR = 0·87; 95 % CI (0·78, 0·97); = 0·014). In addition, there was no evidence of an increased risk of glioma in the heavy alcohol drinking compared with non-drinking (RR = 0·89; 95 % CI (0·67, 1·18); = 0·404). The findings suggest an inverse association between low-moderate alcohol drinking and the risk of glioma, in the absence, however, of a dose-response relationship. More prospective studies are needed to provide further insight into the association between alcohol drinking and glioma risk.
饮酒与胶质瘤风险之间的关联已得到广泛研究，但这些结果却相互矛盾。因此，我们进行了这项系统评价和更新的荟萃分析，以系统评估饮酒与胶质瘤风险之间的关联。我们对截至2021年12月在PubMed、Web of Science、中国知网和万方数据库中发表的相关文章进行了系统的文献检索。使用固定效应模型计算相对风险（RR）的合并估计值和95%置信区间（CI）。本荟萃分析共纳入8篇文章，其中3项病例对照研究涉及2706例胶质瘤病例和2189927名参与者。低至中度饮酒显示胶质瘤风险降低，不饮酒者（RR = 0·87；95% CI（0·78，0·97）；P = 0·014）。此外，与不饮酒相比，重度饮酒没有证据表明胶质瘤风险增加（RR = 0·89；95% CI（0·67，1·18）；P = 0·404）。研究结果表明，低至中度饮酒与胶质瘤风险之间存在负相关，但不存在剂量反应关系。需要更多的前瞻性研究来进一步深入了解饮酒与胶质瘤风险之间的关联。
