Gheorghiu Anamaria, Brunborg Cathrine, Johannesen Tom B, Helseth Eirik, Zwart John-Anker, Wiedmann Markus K H
Department of Neurosurgery, Bagdasar-Arseni University Hospital, Bucharest, Romania.
Faculty of Medicine, University of Oslo, Oslo, Norway.
Front Oncol. 2024 Dec 4;14:1471733. doi: 10.3389/fonc.2024.1471733. eCollection 2024.
The identification of modifiable risk factors for intracranial glioma remains a significant challenge. While lifestyle factors and metabolic syndrome are well-established risk factors for various other cancers, their association with glioma risk remains unclear.
This study aims to conduct a comprehensive analysis of lifestyle factors and metabolic factors in relation to glioma risk.
The Cohort of Norway (CONOR) is a prospective, population-based health survey encompassing anthropometric measurements, blood tests and health questionnaires. CONOR data were linked to the National Cancer Registry to identify incident glioma cases. Follow-up time was calculated in person-years from the baseline examination until the date of glioma diagnosis, death, or the end of the follow-up period. Cox proportional hazards regression was used to calculate hazard ratios (HR).
The study cohort included 160,938 women and men. Over 2.8 million person-years of follow-up, 319 intracranial gliomas were diagnosed. Lifestyle factors such as physical activity, alcohol consumption, smoking, and marital status were not associated with glioma risk. There was no increased glioma risk among participants with diabetes mellitus or hypertension. Furthermore, metabolic syndrome in both women and men was not associated with an elevated risk of glioma. Blood lipids, including total cholesterol, triglycerides, and HDL, were not linked to glioma risk. However, increasing LDL levels were associated with a decreased risk of glioma in men (HR per category 0.84; 95% CI 0.74-0.96), but not in women.
This is the first comprehensive prospective cohort study to evaluate potentially modifiable risk factors for glioma. Our findings do not support previously suggested associations between smoking, alcohol consumption, or metabolic syndrome and glioma risk.
确定可改变的颅内胶质瘤风险因素仍然是一项重大挑战。虽然生活方式因素和代谢综合征是多种其他癌症已明确的风险因素，但它们与胶质瘤风险的关联仍不明确。
本研究旨在全面分析生活方式因素和代谢因素与胶质瘤风险的关系。
挪威队列研究（CONOR）是一项基于人群的前瞻性健康调查，包括人体测量、血液检测和健康问卷。CONOR数据与国家癌症登记处相关联，以识别新发胶质瘤病例。随访时间从基线检查之日起以人年计算，直至胶质瘤诊断、死亡或随访期结束。采用Cox比例风险回归计算风险比（HR）。
研究队列包括160,938名男性和女性。在超过280万人年的随访中，诊断出319例颅内胶质瘤。身体活动、饮酒、吸烟和婚姻状况等生活方式因素与胶质瘤风险无关。糖尿病或高血压患者的胶质瘤风险并未增加。此外，男性和女性的代谢综合征均与胶质瘤风险升高无关。血脂，包括总胆固醇、甘油三酯和高密度脂蛋白，与胶质瘤风险无关。然而，低密度脂蛋白水平升高与男性胶质瘤风险降低相关（每类别HR为0.84；95%CI为0.74 - 0.96），但在女性中并非如此。
这是第一项评估胶质瘤潜在可改变风险因素的全面前瞻性队列研究。我们的研究结果不支持先前提出的吸烟、饮酒或代谢综合征与胶质瘤风险之间的关联。
