Xiao Li-Xia, Zhou Hui-Nian, Jiao Zuo-Yi
Second College of Clinical Medicine, Lanzhou University, Lanzhou, China.
Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, China.
Curr Cancer Drug Targets. 2022;23(1):2-14. doi: 10.2174/1568009622666220806121008.
Since their discovery, saikosaponins (SSs) have been found to play an important role in treating a variety of cancers via diverse mechanisms of action. This review summarizes the current research status and prospects of the anti-cancer activities of SSs, providing novel insights into the limitations of current studies. In addition, it discusses whether SSs can be applied in immunotherapy and the possible mechanisms by which SSs may facilitate immunotherapy. The research is significant to understanding the anti-cancer potents of SSs in the development of SSs-based therapeutic strategies and clinical practice.
自发现以来，柴胡皂苷（SSs）已被发现通过多种作用机制在治疗多种癌症中发挥重要作用。本综述总结了柴胡皂苷抗癌活性的当前研究现状和前景，为当前研究的局限性提供了新的见解。此外，还讨论了柴胡皂苷是否可应用于免疫治疗以及柴胡皂苷可能促进免疫治疗的潜在机制。该研究对于在基于柴胡皂苷的治疗策略开发和临床实践中理解柴胡皂苷的抗癌潜力具有重要意义。
