Department of Dermatology, The Saarland University Hospital, Homburg, Germany.
Adv Exp Med Biol. 2020;1218:9-37. doi: 10.1007/978-3-030-34436-8_2.
The evolutionary highly conserved Notch pathway, which first developed during evolution in metazoans and was first discovered in fruit flies (Drosophila melanogaster), governs many core processes including cell fate decisions during embryonic development. A huge mountain of scientific evidence convincingly demonstrates that Notch signaling represents one of the most important pathways that regulate embryogenesis from sponges, roundworms, Drosophila melanogaster, and mice to humans. In this review, we give a brief introduction on how Notch orchestrates the embryonic development of several selected tissues, summarizing some of the most relevant findings in the central nervous system, skin, kidneys, liver, pancreas, inner ear, eye, skeleton, heart, and vascular system.
进化上高度保守的 Notch 通路首先在后生动物的进化中形成，并在果蝇（Drosophila melanogaster）中首次发现，它控制着许多核心过程，包括胚胎发育过程中的细胞命运决定。大量确凿的科学证据表明，Notch 信号代表了调控从海绵动物、线虫、果蝇和小鼠到人等生物体胚胎发生的最重要途径之一。在这篇综述中，我们简要介绍了 Notch 如何协调几个选定组织的胚胎发育，总结了中枢神经系统、皮肤、肾脏、肝脏、胰腺、内耳、眼睛、骨骼、心脏和脉管系统中一些最相关的发现。
