Department of Medicine, Military Hospital Wellington, Coonoor, Nilgiris, Tamil Nadu, India.
Department of Nephrology, Medical Division, Command Hospital Air Force, Bengaluru, Karnataka, India.
Saudi J Kidney Dis Transpl. 2021 Nov-Dec;32(6):1826-1829. doi: 10.4103/1319-2442.352449.
Anaphylaxis is an acute, severe, and potentially lethal form of an allergic reaction. It can lead to a sepsis-like syndrome and multisystem involvement with complications. It can cause distributive shock with preferential blood supply to vital organs, at the expense of blood supply to skeletal muscle. Skeletal muscle ischemia leads to the fast depletion of myocyte energy source and a cascade of inflammatory reactions leading to myocyte injury and death. Myocyte lysis or rhabdomyolysis releases the cellular contents into circulation. Rhabdomyolysis is not an oft-discussed complication of anaphylaxis. We describe a 21-year-old male with no known comorbidity who presented with anaphylactic shock after consuming one tablet paracetamol + ibuprofen and was found to have rhabdomyolysis-related acute kidney injury.
过敏反应是一种急性、严重且潜在致命的过敏反应形式。它可能导致类似脓毒症的综合征和多系统受累，伴有并发症。它可能导致分布性休克，优先向重要器官供血，而牺牲骨骼肌的血液供应。骨骼肌缺血导致肌细胞能量源迅速耗尽，并引发一系列炎症反应，导致肌细胞损伤和死亡。肌细胞溶解或横纹肌溶解将细胞内容物释放到循环中。横纹肌溶解并不是过敏反应的常见并发症。我们描述了一名 21 岁男性，无已知合并症，在服用一片对乙酰氨基酚+布洛芬后出现过敏性休克，被发现存在与横纹肌溶解相关的急性肾损伤。
