Department of Internal Medicine, Giresun University, Giresun, Turkey.
J Pak Med Assoc. 2024 Sep;74(9):1695-1698. doi: 10.47391/JPMA.10501.
Rhabdomyolysis is a clinical condition characterized by the release of intracellular content into the bloodstream, resulting in the breakdown of skeletal muscle. The released intracellular content includes electrolytes, enzymes, and myoglobin, leading to systemic complications. The clinical presentation may vary, ranging from an asymptomatic increase in serum levels of enzymes released from damaged muscles to worrisome conditions such as volume depletion, metabolic and electrolyte abnormalities, and acute kidney injury. The diagnosis is confirmed when the serum creatine kinase (CK) level is > 1000 U/L or at least 5x the upper limit of normal. In this study, we aimed to evaluate a 21-year-old female patient presenting with nontraumatic exercise-unrelated rhabdomyolysis, accompanied by acute renal failure and septic shock.
横纹肌溶解症是一种临床病症，其特征是细胞内物质释放到血液中，导致骨骼肌破裂。释放的细胞内物质包括电解质、酶和肌红蛋白，导致全身并发症。临床表现多种多样，从无症状的血清酶升高到令人担忧的情况，如容量不足、代谢和电解质异常以及急性肾损伤。当血清肌酸激酶（CK）水平>1000 U/L 或至少是正常上限的 5 倍时，即可确诊。在这项研究中，我们旨在评估一位 21 岁的女性患者，她因非创伤性、与运动无关的横纹肌溶解症导致急性肾衰竭和感染性休克。
