College of Life Sciences, Shandong Normal University, Jinan, China.
Institute of Agricultural Products Processing and Nutrition Research, Shandong Academy of Agricultural Sciences/Key Laboratory of Agro-Products Processing Technology of Shandong Province/Shandong Engineering Technology Research Center of food for Special Medical Purpose/Key Laboratory of Novel Food Resources Processing, Ministry of Agriculture and Rural Affairs, Jinan, China.
Food Funct. 2022 Aug 30;13(17):8766-8782. doi: 10.1039/d1fo03204f.
: To investigate the effect of oligosaccharides on the markers of glycemic control, including fasting blood glucose (FBG), fasting blood insulin (FBI), glycated hemoglobin (HbA), homeostasis model assessment of insulin resistance (HOMA-IR), and quantitative insulin sensitivity index (QUICKI). : PubMed, Embase, and the Cochrane Library databases were systematically searched to find randomized controlled trials (RCTs) on the effect of oligosaccharide intervention on FBG, FBI, HbA, HOMA-IR, and QUICKI up to 7 June 2021. Data were pooled using weighted mean difference (WMD) and 95% confidence intervals (95% CI), with a -value ≤0.05 indicating statistical significance. Risk of bias was assessed with the Cochrane tool and the quality of the literature with the new Jadad scale. : A total of 46 randomized controlled trials were included. Oligosaccharides significantly reduced FBG (WMD: -0.295 mmol L; 95% CI: -0.396 to -0.193; < 0.001; = 90.9%; 46 trials; 2412 participants), FBI (WMD: -0.559 pmol L; 95% CI: -0.939 to -0.178; < 0.01; = 99.1%; 29 trials; 1462 participants), HbA (WMD: -0.365; 95% CI: -0.725 to -0.005; < 0.05; = 86.6%; 11 trials; 661 participants), and HOMA-IR (WMD: -0.793; 95% CI: -1.106 to -0.480; < 0.001; = 96.1%; 24 trials; 1382 participants). Oligosaccharides were more beneficial for the participants with obesity or diabetes than for healthy participants. Multiple interventions per day consolidated the effectiveness of oligosaccharides. Regardless of the processing manner (starch-modified or naturally extracted) of the oligosaccharides, their intervention was overall beneficial for the patients with diabetes. : This study is by far the most extensive systematic review to evaluate the role of oligosaccharides on the markers of glycemic control. Oligosaccharide interventions can exert beneficial effects on FBG, FBI, HbA, and HOMA-IR.
研究低聚糖对血糖控制标志物的影响，包括空腹血糖（FBG）、空腹血胰岛素（FBI）、糖化血红蛋白（HbA）、胰岛素抵抗评估的稳态模型（HOMA-IR）和定量胰岛素敏感性指数（QUICKI）。方法：系统检索PubMed、Embase 和 Cochrane Library 数据库，以查找截至 2021 年 6 月 7 日低聚糖干预对 FBG、FBI、HbA、HOMA-IR 和 QUICKI 影响的随机对照试验（RCT）。使用加权均数差（WMD）和 95%置信区间（95%CI）汇总数据， = 0.05 表示有统计学意义。使用 Cochrane 工具评估偏倚风险，使用新 Jadad 量表评估文献质量。结果：共纳入 46 项 RCT。低聚糖可显著降低 FBG（WMD：-0.295 mmol/L；95%CI：-0.396 至 -0.193； < 0.001； = 90.9%；46 项试验；2412 名参与者）、FBI（WMD：-0.559 pmol/L；95%CI：-0.939 至 -0.178； < 0.01； = 99.1%；29 项试验；1462 名参与者）、HbA（WMD：-0.365；95%CI：-0.725 至 -0.005； < 0.05； = 86.6%；11 项试验；661 名参与者）和 HOMA-IR（WMD：-0.793；95%CI：-1.106 至 -0.480； < 0.001； = 96.1%；24 项试验；1382 名参与者）。低聚糖对肥胖或糖尿病患者的影响优于健康参与者。每日多次干预可增强低聚糖的效果。无论低聚糖的加工方式（淀粉修饰或天然提取）如何，其干预措施总体上对糖尿病患者有益。结论：这是迄今为止评估低聚糖对血糖控制标志物影响的最广泛系统综述。低聚糖干预可对 FBG、FBI、HbA 和 HOMA-IR 产生有益影响。
