Department of Physiology, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, the Netherlands.
Amsterdam Cardiovascular Sciences, Microcirculation, Amsterdam, the Netherlands.
Clin Sci (Lond). 2022 Aug 12;136(15):1157-1178. doi: 10.1042/CS20210994.
Cardiovascular diseases are the leading cause of death and debility worldwide. Various molecular mechanisms have been studied to better understand the development and progression of cardiovascular pathologies with hope to eradicate these diseases. With the advancement of the sequencing technology, it is revealed that the majority of our genome is non-coding. A growing body of literature demonstrates the critical role of long non-coding RNAs (lncRNAs) as epigenetic regulators of gene expression. LncRNAs can regulate cellular biological processes through various distinct molecular mechanisms. The abundance of lncRNAs in the cardiovascular system indicates their significance in cardiovascular physiology and pathology. LncRNA H19, in particular, is a highly evolutionarily conserved lncRNA that is enriched in cardiac and vascular tissue, underlining its importance in maintaining homeostasis of the cardiovascular system. In this review, we discuss the versatile function of H19 in various types of cardiovascular diseases. We highlight the current literature on H19 in the cardiovascular system and demonstrate how dysregulation of H19 induces the development of cardiovascular pathophysiology.
心血管疾病是全球范围内导致死亡和身体虚弱的主要原因。为了更好地了解心血管病变的发生和发展，人们研究了各种分子机制，以期消除这些疾病。随着测序技术的进步，人们发现我们的基因组大部分是非编码的。越来越多的文献表明，长非编码 RNA（lncRNA）作为基因表达的表观遗传调节剂具有重要作用。lncRNA 可以通过各种不同的分子机制来调节细胞的生物学过程。心血管系统中 lncRNA 的丰富性表明它们在心血管生理学和病理学中的重要性。特别是 lncRNA H19，是一种高度进化保守的 lncRNA，在心脏和血管组织中富集，这突出了它在维持心血管系统内环境稳定中的重要性。在这篇综述中，我们讨论了 H19 在各种类型的心血管疾病中的多功能作用。我们强调了 H19 在心血管系统中的现有文献，并展示了 H19 的失调如何导致心血管病理生理学的发展。
