Chongqing Key Laboratory of Ultrasound Molecular Imaging, Institute of Ultrasound Imaging, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China.
Nanoscale. 2022 Aug 25;14(33):12069-12076. doi: 10.1039/d2nr02848d.
Near-infrared (NIR) laser triggered theranostic platforms are increasingly used in clinical nanomedicine applications. In this work, a core-shell composite consisting of polypyrrole (PPy) coated copper sulfide (CuS) nanospheres with high photothermal efficiency and good photostability has been fabricated a facile interfacial polymerization. The PPy@CuS nanohybrid had a hydrodynamic diameter of 58.5 nm with a CuS core and PPy shell and exhibited strong optical absorption and photon-to-heat conversion in the NIR region, leading to a sufficient photohyperthermic effect under irradiation with a 808 nm continuous wave laser. studies showed that the Ppy@CuS nanohybrids produced significant photoacoustic signals and exhibited remarkable photothermal therapeutic efficacy. Furthermore, the core-shell composites exhibited improved temperature elevation and photostability. The temperature-induced changes can be detected and monitored using photoacoustic imaging, thus allowing the control of the thermal dose while minimizing photothermal damage to surrounding healthy tissues. In summary, this study demonstrates that this novel platform could potentially be used for photoacoustic image-guided photothermal therapy and real-time temperature monitoring in cancer theranostics.
近红外（NIR）激光触发的治疗平台越来越多地应用于临床纳米医学领域。在这项工作中，通过简单的界面聚合，制备了一种具有高光热效率和良好光稳定性的聚吡咯（PPy）包覆硫化铜（CuS）纳米球的核壳复合材料。PPy@CuS 纳米杂化物具有 58.5nm 的水动力直径，具有 CuS 核和 PPy 壳，在近红外区域表现出强的光吸收和光热转换，在 808nm 连续波激光照射下产生足够的光热效应。研究表明，PPy@CuS 纳米杂化物产生了显著的光声信号，并表现出显著的光热治疗效果。此外，核壳复合材料表现出改善的温度升高和光稳定性。可以使用光声成象来检测和监测温度诱导的变化，从而在最小化光热损伤周围健康组织的同时控制热剂量。总之，本研究表明，这种新型平台可用于光声图像引导的光热治疗和癌症治疗中的实时温度监测。
