College of Biological Resources and Food Engineering, Qujing Normal University, Qujing 655011, China.
Department of Pharmacy, Qujing Maternal and Chile Health Hospital, Qujing 655000, China.
J Asian Nat Prod Res. 2023 Jun;25(6):540-546. doi: 10.1080/10286020.2022.2109148. Epub 2022 Aug 10.
Three new C-diterpenoid alkaloids, nagarumines A-C (), together two known alkaloids, deoxyaconitine () and N-deethyldeoxyaconitine (), were isolated from the roots of . The structures of the new compounds were elucidated by spectral methods such as 1D and 2D (H-H COSY, HMQC, and HMBC) NMR spectroscopy, as well as high resolution mass spectrometry. The pharmacological studies revealed that nagarumine C () possessed comparable antinociceptive activity (ED = 76.0 μmol/kg) with the positive control drugs aspirin and acetaminophen.
从 中分离得到三种新的 C-二萜生物碱，那嘎林胺 A-C（），以及两种已知的生物碱，脱氧乌头碱（）和 N-去乙基脱氧乌头碱（）。新化合物的结构通过光谱方法如 1D 和 2D（H-H COSY、HMQC 和 HMBC）NMR 光谱以及高分辨质谱来阐明。药理研究表明，那嘎林胺 C（）具有与阳性对照药物阿司匹林和对乙酰氨基酚相当的镇痛活性（ED = 76.0 μmol/kg）。
