从 中分离得到的具有镇痛作用的 C-二萜生物碱。
Antinociceptive C-diterpenoid alkaloids isolated from .
机构信息
College of Biological Resources and Food Engineering, Qujing Normal University, Qujing 655011, China.
Tumor Hospital of Yunnan Province, The Third Affiliated Hospital of Kunming Medical University, Kunming 650118, China.
出版信息
J Asian Nat Prod Res. 2021 Jul;23(7):637-643. doi: 10.1080/10286020.2021.1886091. Epub 2021 Feb 15.
Phytochemical investigation on the roots of resulted in the isolation of three new aconitine-type C-diterpenoid alkaloids, pseudostapines A-C (). Their structures were determined by spectral methods such as 1D and 2D (HH COSY, HMQC, NOESY and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. The isolated alkaloids were tested for their antinociceptive potential. As a result, pseudostapine C () showed 2-fold more potent antinociceptive effect (ID = 60.3 μmol/kg) than the positive control drugs aspirin and acetaminophen.
从 的根部分离得到三种新的乌头型 C-二萜生物碱，伪石松 A-C（）。通过光谱方法如 1D 和 2D（HH COSY、HMQC、NOESY 和 HMBC）NMR 光谱以及高分辨质谱确定了它们的结构。测试了分离得到的生物碱的镇痛活性。结果表明，伪石松 C（）的镇痛效果比阳性对照药物阿司匹林和对乙酰氨基酚强 2 倍（ID = 60.3 μmol/kg）。
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