他汀类药物暴露与胃癌发病和预后的关系：一项更新的荟萃分析。
Association between statins' exposure with incidence and prognosis of gastric cancer: an updated meta-analysis.
机构信息
The First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Department of General Surgery, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang, China.
出版信息
Expert Rev Clin Pharmacol. 2022 Sep;15(9):1127-1138. doi: 10.1080/17512433.2022.2112178. Epub 2022 Aug 15.
BACKGROUND AND AIMS
Previous research has revealed the role of statins in cancer prevention and treatment. This study aimed to determine the relationship between statins' exposure and the incidence and prognosis of gastric cancer (GC).
METHODS
Relevant articles until January 2022 were systematically searched in PubMed, EBSCO, Web of Science, and Cochrane Library databases for comparison in GC with or without statins' exposure. The primary referred outcomes were the occurrence of GC and the survival rate. A total of 19 articles were included in this meta-analysis.
RESULTS
The analysis showed that statins were associated with reduced GC incidence and increased GC survival rate. Subgroup analysis suggested a decreased incidence of GC in both Eastern and Western countries exposed to statins. Furthermore, the risk of GC was reduced in those exposed to lipophilic statins, yet not in those exposed to hydrophilic statins.
CONCLUSIONS
Statins were found to help lower the incidence and improve the survival rate of GC. Furthermore, the incidence of GC was influenced by the population's origin region and the type of statins used.
背景与目的
既往研究揭示了他汀类药物在癌症预防和治疗中的作用。本研究旨在确定他汀类药物暴露与胃癌（GC）发病和预后的关系。
方法
系统检索 PubMed、EBSCO、Web of Science 和 Cochrane Library 数据库中截至 2022 年 1 月的相关文献，以比较 GC 患者与未暴露于他汀类药物的患者。主要参考结局为 GC 的发生和生存率。本荟萃分析共纳入 19 项研究。
结果
分析表明，他汀类药物与 GC 发病率降低和 GC 生存率升高相关。亚组分析表明，暴露于他汀类药物的东西方国家 GC 发病率均降低。此外，脂溶性他汀类药物暴露者的 GC 发病风险降低，但亲水性他汀类药物暴露者的 GC 发病风险无降低。
结论
他汀类药物有助于降低 GC 的发病率和提高生存率。此外，GC 的发病率受到人群来源地区和所使用的他汀类药物类型的影响。
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