铑（III）催化的区域选择性C-H活化双烯基化/环化级联反应，用于快速合成6-异吲哚并[2,1-]吲哚。
Rh(iii)-catalyzed regioselective C-H activation dialkenylation/annulation cascade for rapid access to 6-isoindolo[2,1-]indole.
作者信息
Zhang Fangming, Zhu Xin, Luo Bo, Wang Chengming
机构信息
Department of Chemistry, College of Chemistry and Materials Science, Jinan University Guangzhou 511443 China
出版信息
RSC Adv. 2021 Jul 20;11(41):25194-25198. doi: 10.1039/d1ra02998c. eCollection 2021 Jul 19.
Abstract
6-isoindolo[2,1-]indoles were accessed a Rh(iii)-catalyzed N-H free indole directed C-H activation dialkenylation/annulation cascade in moderate to excellent yields. This protocol also features: reaction procedures that are insensitive to air and moisture, excellent regioselectivity and good functional group tolerance.
摘要
通过铑（III）催化的无N-H吲哚导向的C-H活化双烯基化/环化串联反应，以中等至优异的产率得到了6-异吲哚并[2,1-]吲哚。该方法还具有以下特点：反应过程对空气和水分不敏感、区域选择性优异且官能团耐受性良好。
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