联合氧化剂能力、氧化还原加权氧化剂能力与血压升高：一项队列研究。

Combined oxidant capacity, redox-weighted oxidant capacity and elevated blood pressure: A panel study.

作者信息

Yuan Zhi, Chen Ping, Yang Liyan, Miao Lin, Wang Hua, Xu Dexiang, Lin Zhijing

机构信息

Department of Toxicology, School of Public Health, Anhui Medical University, Hefei 230032, China.

Department of Toxicology, School of Public Health, Anhui Medical University, Hefei 230032, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Anhui Medical University, Hefei 230032, China.

出版信息

Ecotoxicol Environ Saf. 2022 Apr 1;234:113364. doi: 10.1016/j.ecoenv.2022.113364. Epub 2022 Mar 4.

DOI:10.1016/j.ecoenv.2022.113364

PMID:35255254

Abstract

BACKGROUND

Evidence is limited on the potential health effects of O (sum value) and O(weighted value), the two surrogates for ozone (O) and nitrogen dioxides (NO).

OBJECTIVES

To investigate the impacts of O and redox-weighted oxidant capacity (O) on blood pressure (BP).

METHODS

A panel study was conducted with four repeated follow-up visits among 40 healthy college students in Hefei, Anhui Province, China from August to October, 2021. We measured BP by using an automated sphygmomanometer and obtained hourly data of air pollutants at a nearby site. The sum of O and NO (O) and their weighted average (O) were obtained as exposure variables. We applied linear mixed-effect models to evaluate the effects of O and Oon systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP) and pulse pressure (PP).

RESULTS

Totally, 160 pairs of valid BP values were obtained. The 24-h mean levels of O and O were 64.38 μg/m and 110.28 μg/m, respectively. Overall, both O and O were significantly linked with SBP, DBP and MAP at most lag periods, whereas non-significant with PP. A 10-μg/m increase in O at lag 0-24 h was linked to increases of 2.43 mmHg (95% CI: 0.96, 3.91) in SBP, 2.31 mmHg (95% CI: 1.37, 3.26) in DBP and 2.35 mmHg (95% CI: 1.35, 3.36) in MAP, while the corresponding effect estimates for O were 1.51 mmHg (95%CI: 0.60, 2.43), 1.43 mmHg (95% CI: 0.85, 2.02) and 1.46 mmHg (95%CI: 0.83, 2.09). In two-pollutant models, our results were almost unchanged after controlling for simultaneous exposure to other pollutants. The effects were more pronounced among males and those with physical activity.

CONCLUSIONS

The findings provide first-hand evidence that short-term exposure to O and O was associated with BP increases in young adults.

摘要

背景

关于臭氧（O₃）和二氧化氮（NO₂）的两种替代指标O₃（总和值）和O₃（加权值）对健康的潜在影响，证据有限。

目的

研究O₃和氧化还原加权氧化剂能力（O₃）对血压（BP）的影响。

方法

2021年8月至10月，对中国安徽省合肥市40名健康大学生进行了一项有四次重复随访的队列研究。我们使用自动血压计测量血压，并在附近站点获取每小时的空气污染物数据。获得O₃和NO₂的总和（Oₓ）及其加权平均值（O₃w）作为暴露变量。我们应用线性混合效应模型来评估Oₓ和O₃w对收缩压（SBP）、舒张压（DBP）、平均动脉压（MAP）和脉压（PP）的影响。

结果

共获得160对有效的血压值。Oₓ和O₃w的24小时平均水平分别为64.38μg/m³和110.28μg/m³。总体而言，在大多数滞后时间段，Oₓ和O₃w均与SBP、DBP和MAP显著相关，而与PP无显著相关性。在滞后0 - 24小时时，Oₓ每增加10μg/m³，SBP升高2.43mmHg（95%CI：0.96，3.91），DBP升高2.31mmHg（95%CI：1.37，3.26），MAP升高2.35mmHg（95%CI：1.35，3.36），而O₃w的相应效应估计值分别为1.51mmHg（95%CI：0.60，2.43）、1.43mmHg（95%CI：0.85，2.02）和1.46mmHg（95%CI：0.83，2.09）。在双污染物模型中，在控制同时暴露于其他污染物后，我们的结果几乎没有变化。在男性和有体育活动的人群中，这些影响更为明显。