McWhinney B C, Nagel S L, Cowley D M, Brown J M, Chalmers A H
Clin Chem. 1987 Jul;33(7):1118-20.
We used a xylitol load to test the two-carbon pathway to oxalate production in humans. Use of this pentose sugar caused a fourfold increase in glycolate excretion, indicating its suitability as a dynamic function test of two-carbon metabolism. However, despite this increase in glycolate excretion in 10 recurrent stone formers and six normal subjects, there was no concomitant increase in oxalate excretion in either group. By comparison, a sucrose load produced no increase in excretion of either glycolate or oxalate. In addition, when we studied four recurrent calcium stone formers on successive diets with various fat content, we found no correlation between high fat intake and increased glycolate or oxalate excretion. In summary, there was no evidence of abnormal fluxes through the two-carbon pathway to oxalate in recurrent stone formers, nor of hyperoxaluria as related to increased intake of sucrose or fat.
我们使用木糖醇负荷试验来检测人体中草酸生成的双碳途径。使用这种戊糖导致乙醇酸排泄量增加了四倍，表明其适合作为双碳代谢的动态功能测试。然而，尽管10名复发性结石形成者和6名正常受试者的乙醇酸排泄量有所增加，但两组的草酸盐排泄量均未随之增加。相比之下，蔗糖负荷并未使乙醇酸或草酸盐的排泄量增加。此外，当我们研究4名复发性钙结石形成者在连续食用不同脂肪含量的饮食时，我们发现高脂肪摄入与乙醇酸或草酸盐排泄增加之间没有相关性。总之，没有证据表明复发性结石形成者通过双碳途径生成草酸的通量异常，也没有证据表明高草酸尿症与蔗糖或脂肪摄入量增加有关。
