Lundquist P, Rosling H, Sörbo B, Tibbling L
Clin Chem. 1987 Jul;33(7):1228-30.
Using the sensitive fluorimetric method described here, we evaluated the determination of blood cyanide as a method for monitoring exposure to tobacco smoke. The mean concentration of cyanide in blood from eight nonsmokers was 0.098 (SD 0.036) mumol/L. The concentration of cyanide in blood of smokers who had refrained from smoking for at least 2 h before sampling peaked immediately after the subjects smoked a cigarette, then rapidly declined, with a half-life of about 4 min. Its rapid disappearance from blood makes cyanide an unsuitable marker of exposure to tobacco smoke. Because the ability of patients with hepatic dysfunction to detoxify cyanide has been presumed to be impaired, we monitored the concentrations of cyanide in the blood of four patients with severe hepatic insufficiency who smoked a cigarette. The rate of elimination of cyanide from blood after smoking was only slightly less in these patients than in the controls, and the difference was not statistically significant.
使用此处描述的灵敏荧光法，我们评估了血液中氰化物的测定作为监测烟草烟雾暴露的一种方法。八名不吸烟者血液中氰化物的平均浓度为0.098（标准差0.036）微摩尔/升。在采样前至少2小时未吸烟的吸烟者，在其吸完一支烟后，血液中氰化物浓度立即达到峰值，然后迅速下降，半衰期约为4分钟。氰化物在血液中的快速消失使其成为烟草烟雾暴露的不合适标志物。由于肝功能不全患者解毒氰化物的能力被认为受损，我们监测了四名重度肝功能不全且吸烟的患者血液中氰化物的浓度。这些患者吸烟后血液中氰化物的消除速率仅略低于对照组，差异无统计学意义。
