Shani A, Ritts R E, Thynne G S, Weiland L H, Silvers A, Moertel C G, Go V L
Int J Cancer. 1978 Aug 15;22(2):113-9. doi: 10.1002/ijc.2910220202.
Fifty-four patients from the surgical gastroenterology service and 22 healthy controls have been prospectively evaluated in a single-blind protocol by the LAI tube method. The LAI correctly identified 25 of 33 early colorectal patients staged as Dukes' B and C at surgery but none of the Dukes' D patients. An inverse relationship was seen between the results of the non-adherence index (NAI) and CEA levels which was most pronounced in those with advanced colorectal cancer. The majority of Dukes' B and C patients having a "false negative" LAI had a CEA level greater than 2.5 ng/ml, suggesting that more advanced disease than that seen at surgery may be present. Two of 22 normal controls gave a borderline positive NAI. Some technical problems, including the relatively short life of the tumor extracts, are discussed.
采用LAI管法，对54例来自外科胃肠病科的患者和22名健康对照者进行了单盲方案的前瞻性评估。LAI正确识别出33例手术分期为Dukes B期和C期的早期结直肠癌患者中的25例，但未识别出任何Dukes D期患者。在非依从性指数（NAI）结果与癌胚抗原（CEA）水平之间发现了一种负相关关系，这在晚期结直肠癌患者中最为明显。大多数LAI结果为“假阴性”的Dukes B期和C期患者CEA水平大于2.5 ng/ml，这表明可能存在比手术所见更晚期的疾病。22名正常对照者中有2人NAI结果呈临界阳性。文中讨论了一些技术问题，包括肿瘤提取物的保存时间相对较短。
