Mounielou P M, Clemente F, Estival A, Ribet A
Gastroenterol Clin Biol. 1984 Oct;8(10):736-41.
The leukocyte adherence inhibition test (LAI) is an in vitro test of immunity. Its high sensitivity in early cancer and its organ-specificity are of great interest in the study of human tumors. We developed an isotopic method (51Cr-LAI) for colorectal cancer, which has the advantage of being easier to perform than optic-counting assays. 87 patients (35 colorectal cancers, 29 benign diseases, 23 cancers of non-colorectal origin) were studied. We obtained a statistically significant difference between the mean LAI index for colorectal cancers and that for controls (p less than 0.01). LAI values greater than 13 p. 100 were considered positive. The specificity of the test was 94 p. 100 and the sensitivity for all colorectal cancers was 66 p. 100 with the highest value in the Dukes A group (LAI = 83 p. 100). Tests were negative in disseminated neoplasms. The actual fields of interest of LAI in tumor immunology and clinical research are discussed.
白细胞黏附抑制试验（LAI）是一种体外免疫试验。它在早期癌症中的高敏感性及其器官特异性在人类肿瘤研究中备受关注。我们开发了一种用于结直肠癌的同位素方法（51Cr-LAI），该方法比光学计数测定法更易于操作。对87例患者（35例结直肠癌、29例良性疾病、23例非结直肠起源的癌症）进行了研究。我们发现结直肠癌的平均LAI指数与对照组之间存在统计学上的显著差异（p小于0.01）。LAI值大于13%被认为是阳性。该试验的特异性为94%，所有结直肠癌的敏感性为66%，在Dukes A组中值最高（LAI = 83%）。在播散性肿瘤中试验为阴性。文中讨论了LAI在肿瘤免疫学和临床研究中的实际关注领域。
