Faculty of Health Sciences, Department of Nutrition and Dietetics, Gazi University, Bişkek st., 06490, Ankara, Turkey.
Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey.
Curr Nutr Rep. 2022 Dec;11(4):753-764. doi: 10.1007/s13668-022-00432-1. Epub 2022 Aug 11.
This study was conducted to determine the effects of antioxidant supplementation on endometriosis-related chronic pelvic pain, dysmenorrhea, and dyspareunia.
PubMed/MEDLINE, Scopus, and Cochrane Library databases and the Google Scholar search engine were searched from early 2012 to 2022 using appropriate keywords for clinical trials receiving antioxidant supplements and reporting endometriosis-related pelvic pain (PROSPERO registration number CRD42022318924). The qualities of the included studies were evaluated using the Joanna Briggs Institute (JBI) Checklists Critical Appraisal Tools and the National Institutes of Health (NIH) quality assessment tool for before-after (Pre-Post) study with no control group. This systematic review was reported according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guideline.
In this systematic review, 8 studies (5 RCTs and 3 non-comparative trials) published in 2012-2022 were included.
The studies we included showed promising results in the use of antioxidants in endometriosis-related pain. However, many scientific studies are needed for clear statements.
本研究旨在确定抗氧化剂补充剂对与子宫内膜异位症相关的慢性盆腔痛、痛经和性交痛的影响。
从 2012 年初到 2022 年，使用接受抗氧化剂补充剂并报告与子宫内膜异位症相关的盆腔疼痛的临床试验的适当关键字，在 PubMed/MEDLINE、Scopus 和 Cochrane Library 数据库以及 Google Scholar 搜索引擎中进行搜索（PROSPERO 注册号 CRD42022318924）。使用 Joanna Briggs 研究所（JBI）清单批判性评估工具和美国国立卫生研究院（NIH）无对照组前后（Pre-Post）研究质量评估工具评估纳入研究的质量。本系统评价按照系统评价和荟萃分析的首选报告项目（PRISMA）指南进行报告。
在本系统评价中，纳入了 8 项研究（5 项 RCT 和 3 项非对照试验），发表于 2012-2022 年。
我们纳入的研究表明，抗氧化剂在与子宫内膜异位症相关的疼痛中的应用有一定的效果。然而，需要更多的科学研究来明确结论。
