Independent Laboratory of Minimally Invasive Gynecology and Gynecological Endocrinology, Medical University of Lublin, 20-059 Lublin, Poland.
Student Scientific Association, Independent Laboratory of Minimally Invasive Gynecology and Gynecological Endocrinology, Medical University of Lublin, 20-059 Lublin, Poland.
Int J Mol Sci. 2024 Jun 7;25(12):6298. doi: 10.3390/ijms25126298.
Endometriosis in half of affected women is closely related to problems with fertility. Endometriosis-associated infertility is caused by a wide range of abnormalities affecting the female reproductive tract, from oocyte quality impairment to disturbances in the eutopic endometrium or mechanical abnormalities resulting from disease progression. Since supportive antioxidant therapies, in addition to surgical treatment or assisted reproductive techniques (ARTs), have overall been proven to be effective tools in endometriosis management, the objective of our review was to analyze the role of antioxidant substances, including vitamins, micronutrients, N-acetylcysteine (NAC), curcumin, melatonin, and resveratrol, in endometriosis-related infertility. Most of these substances have been proven to alleviate the systemic oxidant predominance, which has been expressed through decreased oxidative stress (OS) markers and enhanced antioxidative defense. In addition, we demonstrated that the predominant effect of the aforementioned substances is the inhibition of the development of endometriotic lesions as well as the suppression of pro-inflammatory molecules. Although we can undoubtedly conclude that antioxidants are beneficial in fertility support, further studies explaining the detailed pathways of their action are needed.
子宫内膜异位症在一半受影响的女性中与生育问题密切相关。与子宫内膜异位症相关的不孕是由广泛的异常引起的，这些异常影响女性生殖道，从卵母细胞质量受损到在位子宫内膜的紊乱，或疾病进展引起的机械异常。由于抗氧化支持疗法，除了手术治疗或辅助生殖技术（ART）外，总体上已被证明是子宫内膜异位症管理的有效工具，因此我们的综述旨在分析抗氧化物质（包括维生素、微量营养素、N-乙酰半胱氨酸（NAC）、姜黄素、褪黑素和白藜芦醇）在与子宫内膜异位症相关的不孕中的作用。这些物质中的大多数已被证明可以减轻全身性氧化剂优势，这表现为降低氧化应激（OS）标志物和增强抗氧化防御。此外，我们证明，上述物质的主要作用是抑制子宫内膜异位病变的发展以及抑制促炎分子。尽管我们可以毫无疑问地得出结论，抗氧化剂对生育支持有益，但需要进一步的研究来解释它们作用的详细途径。
