应用光相干断层扫描血管造影评估 Posner-Schlossman 综合征患者的黄斑区微血管密度。
Evaluation of macular microvascular density using optical coherence tomography angiography in patients with Posner-Schlossman syndrome.
机构信息
Department of Ophthalmology, Affiliated Foshan Hospital, Southern Medical University, Foshan, 528000, People's Republic of China.
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Centre, Sun Yat-Sen University, Guangzhou, 510000, People's Republic of China.
出版信息
BMC Ophthalmol. 2022 Aug 10;22(1):339. doi: 10.1186/s12886-022-02563-z.
BACKGROUND
Optical coherence tomography angiography (OCTA) is a novel technology that provides a noninvasive, dye-less method to visualize the blood vessels of the retina. In the present study, we investigate macular microvascular density and the correlation of ocular and demographic factors using OCTA in Posner-Schlossman syndrome (PSS) patients.
METHODS
This is a prospective observational study. All PSS patients and age- and sex-matched healthy subjects underwent complete ophthalmologic examination, and RE, BCVA, IOP, CCT, AL, CMT, GCIPI, RNFL, C/D ratio were recorded. The whole-image vessel density (wiVD) and whole-image perfusion density (wiPD), three-circle (1 mm central ring, 3 mm inner ring, 6 mm outer ring), and four-quadrant segmental VD and PD were calculated.
RESULTS
Seventeen PSS patients and 17 healthy subjects were enrolled in this study. The mean age was 42.65 ± 11.22 years in PSS patients and 42.71 ± 10.50 years in healthy controls. IOP, CCT, and C/D ratio were higher in PSS-attacked eyes, and BCVA, OPP and RNFL thickness was lower than those in the fellow eyes (p < 0.05). BCVA and OPP were improved in the PSS-attacked eyes in intermittent period (p < 0.05). The wiVD and wiPD were lower in the PSS-affected eyes than in the fellow eyes and in the control eyes in the PSS-attacked period (p < 0.05). All segmental VD and PD was lower in the PSS affected eyes than in the healthy control eyes (p < 0.05). In intermittent period, the wiVD and wiPD were lower in the PSS-affected eyes than in the fellow eyes (p < 0.05). Age, CCT, and SSI were associated with macular wiVD and wiPD in PSS attacked period. Age and CCT were associated with macular wiVD and wiPD in PSS intermittent period.
CONCLUSION
Decreased macular superficial VD and PD was found in patients with Posner-Schlossman syndrome in attacked period and in remission. Macular wiVD and wiPD were associated with age, CCT and SSI in PSS patients.
背景
光学相干断层扫描血管造影（OCTA）是一种新型技术，可提供一种无创、无染料的方法来可视化视网膜的血管。本研究通过 OCTA 观察 Posner-Schlossman 综合征（PSS）患者的黄斑微血管密度，并探讨眼部和人口统计学因素的相关性。
方法
这是一项前瞻性观察性研究。所有 PSS 患者和年龄、性别匹配的健康受试者均接受全面眼科检查，并记录视网膜电图（RE）、最佳矫正视力（BCVA）、眼压（IOP）、中央角膜厚度（CCT）、眼轴长度（AL）、角膜中央厚度（CMT）、GCIPI、神经纤维层（RNFL）、杯盘比（C/D 比值）。计算全像血管密度（wiVD）和全像灌注密度（wiPD）、三圈（1mm 中央环、3mm 内环、6mm 外环）和四象限节段性 VD 和 PD。
结果
本研究纳入了 17 例 PSS 患者和 17 例健康对照者。PSS 患者的平均年龄为 42.65±11.22 岁，健康对照组为 42.71±10.50 岁。PSS 攻击眼的眼压、中央角膜厚度和 C/D 比值较高，而 BCVA、眼内压和 RNFL 厚度较低（p<0.05）。PSS 攻击眼在间歇期的 BCVA 和眼内压有所改善（p<0.05）。在 PSS 攻击期，受影响眼的 wiVD 和 wiPD 低于对侧眼和对照组（p<0.05）。所有节段性 VD 和 PD 在 PSS 受影响眼均低于健康对照组（p<0.05）。在间歇期，受影响眼的 wiVD 和 wiPD 低于对侧眼（p<0.05）。年龄、CCT 和 SSI 与 PSS 攻击期的黄斑 wiVD 和 wiPD 相关。年龄和 CCT 与 PSS 间歇期的黄斑 wiVD 和 wiPD 相关。
结论
在攻击期和缓解期，Posner-Schlossman 综合征患者的黄斑浅层 VD 和 PD 减少。黄斑 wiVD 和 wiPD 与 PSS 患者的年龄、CCT 和 SSI 相关。
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