Zhou Li-Jun, Luo Xiu-Zhi, Shen Pei-Yang, Li Xin, Su Peng, Zhu Zhe, Yan Shi-Gang, Kong Xiang-Bin, Lu Xiao-He
Department of Ophthalmology, Zhujiang Hospital, Southern Medical University, Guangzhou, 515282, China.
Department of Ophthalmology, Affiliated Foshan Hospital, Southern Medical University, Foshan, 528000, China.
BMC Ophthalmol. 2021 Mar 20;21(1):140. doi: 10.1186/s12886-021-01896-5.
It is critical to monitor the optic disc's vessel density using Optical coherence tomography angiography (OCTA) and evaluate its determinants. In the current study, we investigate the superficial vessel density (VD) of the papillary microvasculature and its determinants in healthy subjects of Southern China.
This was a prospective, cross-sectional study. Superficial VD in healthy individuals' optic disc region was measured by OCTA. The factors associated with ocular and systemic parameters were analyzed using a generalized estimation equation (GEE) model.
A total of 510 eyes of 260 healthy subjects were analyzed in the study. The total VD in the optic disc area was 17.21 ± 2.15 mm (95% CI, 17.02-17.40 mm). The VD in the inner ring and the outer ring of the optic disc were significantly higher compared with the central ring, while the VD of the superior quadrant and inferior quadrant was significantly higher compared with the temporal and nasal quadrant. After adjusting for the ocular factors and systemic factors, AL (β = - 0.4917, P = 0.0003), disc area (β = - 0.3748, P = 0.0143), CMT (β = - 0.0183, P = 0.0003) and SSI (β = 1.0588, P < 0.001) were significantly associated with total VD of the optic disc.
The mean total VD in the optic disc area was 17.21 ± 2.15 mm in healthy subjects, and the superior and inferior VD was significantly higher than the temporal and nasal VD. AL, disc area, CMT, and SSI may affect the total VD in the optic disc area and should be considered in clinical practice.
使用光学相干断层扫描血管造影（OCTA）监测视盘血管密度并评估其决定因素至关重要。在本研究中，我们调查了中国南方健康受试者视乳头微血管的浅表血管密度（VD）及其决定因素。
这是一项前瞻性横断面研究。通过OCTA测量健康个体视盘区域的浅表VD。使用广义估计方程（GEE）模型分析与眼部和全身参数相关的因素。
本研究共分析了260名健康受试者的510只眼睛。视盘区域的总VD为17.21±2.15mm（95%CI，17.02 - 17.40mm）。视盘内环和外环的VD显著高于中环，而上象限和下象限的VD显著高于颞侧和鼻侧象限。在调整眼部因素和全身因素后，眼轴长度（AL，β = - 0.4917，P = 0.0003）、视盘面积（β = - 0.3748，P = 0.0143）、中央黄斑厚度（CMT，β = - 0.0183，P = 0.0003）和球面等效球镜度（SSI，β = 1.0588，P < 0.001）与视盘总VD显著相关。
健康受试者视盘区域的平均总VD为17.21±2.15mm，上、下VD显著高于颞侧和鼻侧VD。AL、视盘面积、CMT和SSI可能对视盘区域的总VD产生影响，在临床实践中应予以考虑。
