Prioreschi Alessandra, Koethe John R, Aronoff David M, Goldstein Jeffrey A, Norris Shane A
SAMRC/Wits Developmental Pathways for Health Research Unit Department of Paediatrics Faculty of Health Sciences School of Clinical Medicine University of the Witwatersrand Johannesburg South Africa.
Division of Infectious Diseases Department of Medicine Vanderbilt University Medical Center Nashville Tennessee USA.
Obes Sci Pract. 2022 Jan 3;8(4):500-509. doi: 10.1002/osp4.570. eCollection 2022 Aug.
Adipose tissue is a central regulator of metabolic health and a contributor to systemic inflammation. Patterns of adiposity deposition are important to understand for optimizing health. This study aimed to asses relationships between adiposity deposition and metabolic and inflammatory biomarkers in South African women prior to conception.
Non-pregnant, healthy women ( = 298) were recruited for this cross-sectional study via home visits. Body composition was measured by Dual X-ray Absorptiometry. Inflammation markers C-reactive protein (CRP), alpha1-acid glycoprotein (AGP), hemoglobin A1c (HbA1c), and blood pressure were scored according to risk. A summative metabolic health risk score was created for women with obesity. Generalized regression models assessed relationships between adiposity deposition and outcomes with adjustment for potential confounders.
Obesity was present in 22% of women (mean age = 20.93 years). Fat mass index was associated with inflammation and metabolic health risk ( = 0.58; < 0.01). Visceral fat, trunk:limb ratio, android:gynoid ratio, body mass index, weight, and waist circumference were positively associated with CRP, AGP, and metabolic health risk ( < 0.01). Weight was associated with Hba1c ( < 0.01; < 0.05). Participants with obesity and low metabolic health risk had lower fat mass index and visceral fat than participants with obesity and higher metabolic health risk.
Black South African women accumulated excess adipose tissue in abdominal regions. While fat mass and body mass were associated with inflammation and metabolic health risk, women with obesity and with lower fat mass index and lower visceral adipose tissue were metabolically protected. Identification of women at risk for metabolic disease preconception could help ensure future healthy pregnancies and prevent transference of risk to offspring.
脂肪组织是代谢健康的核心调节因子，也是全身性炎症的促成因素。了解肥胖沉积模式对于优化健康状况很重要。本研究旨在评估南非女性受孕前肥胖沉积与代谢和炎症生物标志物之间的关系。
通过家访招募了298名非妊娠健康女性参与这项横断面研究。采用双能X线吸收法测量身体成分。根据风险对炎症标志物C反应蛋白（CRP）、α1-酸性糖蛋白（AGP）、糖化血红蛋白（HbA1c）和血压进行评分。为肥胖女性创建了一个综合代谢健康风险评分。采用广义回归模型评估肥胖沉积与结局之间的关系，并对潜在混杂因素进行校正。
22%的女性存在肥胖（平均年龄=20.93岁）。脂肪量指数与炎症和代谢健康风险相关（r=0.58；P<0.01）。内脏脂肪、躯干与四肢比例、男性化与女性化比例、体重指数、体重和腰围与CRP、AGP和代谢健康风险呈正相关（P<0.01）。体重与糖化血红蛋白相关（P<0.01；P<0.05）。与代谢健康风险较高的肥胖参与者相比，代谢健康风险较低的肥胖参与者的脂肪量指数和内脏脂肪更低。
南非黑人女性在腹部区域积累了过多的脂肪组织。虽然脂肪量和体重与炎症和代谢健康风险相关，但脂肪量指数和内脏脂肪组织较低的肥胖女性在代谢方面受到保护。识别受孕前有代谢疾病风险的女性有助于确保未来的健康妊娠，并防止风险传递给后代。
