Altuwaijri Waleed A, Almutair Angham N, AlAlwan Ibrahim A, Almahdi Maria J, Almasoud Sulaiman D
Department of Pediatrics, Division of Neurology, King Abdulaziz Medical City Riyadh, Riyadh, SAU.
Department of Pediatrics, Division of Endocrinology, King Abdulaziz Medical City Riyadh, Riyadh, SAU.
Cureus. 2022 Aug 8;14(8):e27765. doi: 10.7759/cureus.27765. eCollection 2022 Aug.
Diabetic peripheral neuropathy is a common complication of diabetes mellitus (DM) type 1. However, it can occur without evidence of symptoms or clinical signs of neuropathy labeled as subclinical neuropathy, which neurophysiological studies can best detect.
To evaluate the prevalence of subclinical neuropathy among children with DM type 1, determine the association with blood sugar control, and evaluate the pattern of nerve involvement in neurophysiological studies.
This cross-sectional study evaluated 100 children with DM type 1, aged five to 15 years, at least one year after the diagnosis. Subclinical neuropathy was evaluated using nerve conduction study. Glycemic control was assessed using hemoglobin A1c (HbA1c).
The mean age of subjects was 11.5 ± 0.25 years. The average age at the onset of the disease was 5.95 ± 0.25 years. There were 64 patients who had electrophysiological evidence of peripheral neuropathy. The most observed electrophysiological changes were distal latency abnormalities in the left and right peroneal nerves in 39 and 33 patients, respectively. Sensory nerve amplitude, peak latency, and conduction velocity were normal in all patients (100%). HbA1c level did not show a statistically significant association with the incidence of subclinical neuropathy.
Subclinical neuropathy was prevalent in children with DM type 1. Poor glucose control was only associated with an increased odds ratio of subclinical neuropathy.
糖尿病性周围神经病变是1型糖尿病（DM）的常见并发症。然而，它可能在没有神经病变症状或临床体征的情况下发生，这种情况被称为亚临床神经病变，神经生理学研究能够最好地检测到。
评估1型糖尿病患儿中亚临床神经病变的患病率，确定其与血糖控制的关联，并在神经生理学研究中评估神经受累模式。
这项横断面研究评估了100名年龄在5至15岁之间、诊断后至少一年的1型糖尿病患儿。使用神经传导研究评估亚临床神经病变。使用糖化血红蛋白（HbA1c）评估血糖控制情况。
受试者的平均年龄为11.5±0.25岁。疾病发病的平均年龄为5.95±0.25岁。有64例患者有周围神经病变的电生理证据。最常观察到的电生理变化是分别有39例和33例患者左右腓总神经的远端潜伏期异常。所有患者（100%）的感觉神经振幅、峰潜伏期和传导速度均正常。HbA1c水平与亚临床神经病变的发生率没有统计学上的显著关联。
亚临床神经病变在1型糖尿病患儿中很普遍。血糖控制不佳仅与亚临床神经病变的比值比增加有关。
