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胰腺胰岛素瘤的多种表现形式:病例报告。

Varied presentations of pancreatic insulinoma: a case report.

机构信息

Department of Surgery, Windhoek Central Hospital, Windhoek, Namibia.

Department of Radiology, Windhoek Central Hospital, Windhoek, Namibia.

出版信息

Pan Afr Med J. 2022 May 25;42:69. doi: 10.11604/pamj.2022.42.69.34839. eCollection 2022.

DOI:10.11604/pamj.2022.42.69.34839
PMID:35949463
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9338700/
Abstract

An insulinoma is a rare functional pancreatic neuroendocrine tumour that is usually sporadic and solitary. The hallmark is hypersecretion of insulin, which leads to neuroglycopenia symptoms and uncontrolled sympathoadrenal activity. Neuroendocrine tumours can have a varied presentation, with symptoms often ascribed to a different diagnosis, thus delaying correct diagnosis and treatment. We present the case of a 26-year-old female who had a 3-year delay before diagnosing insulinoma after being initially assessed with epilepsy and schizophrenia. The case report below provides a detailed review of the diagnosis, tumour localization, and surgical interventions implemented for the patient during the COVID-19 pandemic.

摘要

胰岛素瘤是一种罕见的功能性胰腺神经内分泌肿瘤,通常为散发和单发。其特征是胰岛素分泌过多,导致神经低血糖症状和不受控制的交感肾上腺活性。神经内分泌肿瘤的表现形式多种多样,其症状常归因于不同的诊断,从而导致诊断和治疗的延误。我们报告了一例 26 岁女性的病例,她在最初被诊断为癫痫和精神分裂症后,经过 3 年的延迟才被诊断为胰岛素瘤。以下病例报告详细回顾了在 COVID-19 大流行期间为患者实施的诊断、肿瘤定位和手术干预。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b501/9338700/528daf543579/PAMJ-42-69-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b501/9338700/3e8747435446/PAMJ-42-69-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b501/9338700/acd585b21640/PAMJ-42-69-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b501/9338700/e08c4371b2fd/PAMJ-42-69-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b501/9338700/cde6f15b3a0a/PAMJ-42-69-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b501/9338700/a3b74e56c627/PAMJ-42-69-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b501/9338700/528daf543579/PAMJ-42-69-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b501/9338700/3e8747435446/PAMJ-42-69-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b501/9338700/acd585b21640/PAMJ-42-69-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b501/9338700/e08c4371b2fd/PAMJ-42-69-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b501/9338700/cde6f15b3a0a/PAMJ-42-69-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b501/9338700/a3b74e56c627/PAMJ-42-69-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b501/9338700/528daf543579/PAMJ-42-69-g006.jpg

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本文引用的文献

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Patient-Reported Burden of a Neuroendocrine Tumor (NET) Diagnosis: Results From the First Global Survey of Patients With NETs.患者报告的神经内分泌肿瘤(NET)诊断负担:NET患者首次全球调查结果
J Glob Oncol. 2016 Jun 8;3(1):43-53. doi: 10.1200/JGO.2015.002980. eCollection 2017 Feb.
2
Vague neuroglycopenic complaints camouflage diagnosis of adolescent insulinoma: a case report.模糊的神经低血糖症状掩盖了青少年胰岛素瘤的诊断:一例报告
Int J Pediatr Endocrinol. 2016;2016:14. doi: 10.1186/s13633-016-0032-8. Epub 2016 Jul 29.
3
Insulinoma: case report and review of diagnostic and treatment modalities.
胰岛素瘤:病例报告及诊断与治疗方式综述
J Assoc Physicians India. 2013 Jun;61(6):423-6.
4
Diagnosis and management of insulinoma.胰岛素瘤的诊断与治疗。
World J Gastroenterol. 2013 Feb 14;19(6):829-37. doi: 10.3748/wjg.v19.i6.829.
5
Medical treatment of benign insulinoma using octreotide LAR: a case report.使用长效奥曲肽对良性胰岛素瘤进行药物治疗:一例报告
Endocr J. 2007 Feb;54(1):95-101. doi: 10.1507/endocrj.k05-157. Epub 2006 Nov 24.
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Giant insulinoma: case report and review of the literature.巨大胰岛素瘤:病例报告及文献复习
J Clin Endocrinol Metab. 2005 Jan;90(1):575-80. doi: 10.1210/jc.2004-0825. Epub 2004 Nov 2.
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Diagnostic approach to adults with hypoglycemic disorders.成人低血糖症的诊断方法。
Endocrinol Metab Clin North Am. 1999 Sep;28(3):519-32, vi. doi: 10.1016/s0889-8529(05)70086-4.
8
Functioning insulinoma--incidence, recurrence, and long-term survival of patients: a 60-year study.功能性胰岛素瘤——患者的发病率、复发率及长期生存率:一项60年的研究
Mayo Clin Proc. 1991 Jul;66(7):711-9. doi: 10.1016/s0025-6196(12)62083-7.