Klitgaard Allan, Løkke Anders, Lager Jakob, Rasmussen Torben Riis, Hilberg Ole
Department of Regional Health Research, University of Southern Denmark, Odense, Denmark.
Department of Internal Medicine, Lillebaelt Hospital, Vejle, Denmark.
Case Rep Oncol. 2022 Jun 17;15(2):630-635. doi: 10.1159/000525058. eCollection 2022 May-Aug.
Spontaneous regression of cancer is an extremely rare phenomenon, and it has been described in only a few cases of pulmonary cancer. We report a case of complete spontaneous regression of squamous-cell lung cancer (SCLC) following a core needle biopsy in a 67-year-old female patient with two previous lung cancers and concomitant follicular lymphoma. The patient was diagnosed with SCLC after 4 core needle biopsies from a nodule in the left upper lobe and at the same time suspected of having follicular lymphoma. Treatment for the lung cancer was delayed by approximately 8 weeks because the diagnosis of lymphoma was both challenging and time-consuming. A computed tomography scan was performed in relation to the scheduled treatment for SCLC, showing that the pulmonary nodule had disappeared completely. Most other cases of spontaneous regression of lung cancer hint at the involvement of immunological factors, and this case possibly involves a combination of mechanical and local immunological factors. Genetic and immunological analysis of patients showing spontaneous regression of cancers could provide valuable information.
癌症的自发消退是一种极其罕见的现象，仅在少数肺癌病例中有所描述。我们报告一例67岁女性患者，既往有两次肺癌病史且合并滤泡性淋巴瘤，在经皮穿刺活检后，其肺鳞状细胞癌（SCLC）出现完全自发消退。该患者经左上叶结节4次经皮穿刺活检后被诊断为SCLC，同时怀疑患有滤泡性淋巴瘤。由于淋巴瘤的诊断具有挑战性且耗时，肺癌治疗延迟了约8周。针对SCLC的预定治疗进行了计算机断层扫描，结果显示肺部结节已完全消失。肺癌自发消退的大多数其他病例提示免疫因素的参与，本病例可能涉及机械因素和局部免疫因素的综合作用。对癌症出现自发消退的患者进行基因和免疫分析可能会提供有价值的信息。
