Zhang Jingyao, Wang Haijuan, Li Chunxiao, Qian Haili
State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021, China.
Int J Clin Exp Pathol. 2020 May 1;13(5):1190-1196. eCollection 2020.
Spontaneous regression of tumor is an extremely rare phenomenon in the oncology field and even rarer for lung cancer. However, the underlying mechanism is poorly understood. Summarizing the available clinical information and the supposed mechanism shed new light on lung cancer therapy strategies in the new era of immunotherapy.
We conducted a PubMed search using the retrieval tactics ("Lung Neoplasms" [Mesh]) AND "Neoplasm Regression, Spontaneous" [Mesh] for reports from 1988 to January 2018, and all references in the relevant literature were subsequently investigated for relevance. Using the criteria of Everson and Cole, 14 cases were finally defined as spontaneous regression and were reviewed in the research. Key messages: The information regarding patient characteristics, treatments, and follow-up has been summarized. In this review, we found that spontaneous lung cancer regression cases fall into two categories including: (1) neurologic disorders in 6 cases, half of whom suffered with paraneoplastic neurological syndromes (PNS) and (2) immunological reactions in 7 cases. Getting data on more spontaneous regression cases and more detailed information will definitely help us understand the mechanism for the body's surveillance system-cancer balance, creating a big chance to increase cancer immunotherapy.
肿瘤自发消退在肿瘤学领域是极为罕见的现象，在肺癌中更是罕见。然而，其潜在机制尚不清楚。总结现有的临床信息及推测的机制，可为免疫治疗新时代的肺癌治疗策略提供新的思路。
我们使用检索策略（“肺肿瘤”[医学主题词]）和“肿瘤消退，自发”[医学主题词]在PubMed上检索了1988年至2018年1月的报告，随后对相关文献中的所有参考文献进行了相关性调查。根据埃弗森和科尔的标准，最终确定14例为自发消退病例并在研究中进行了回顾。关键信息：总结了有关患者特征、治疗及随访的信息。在本综述中，我们发现肺癌自发消退病例分为两类：（1）6例神经系统疾病，其中一半患有副肿瘤性神经综合征（PNS）；（2）7例免疫反应。获取更多自发消退病例的数据及更详细的信息肯定有助于我们理解机体监测系统与癌症平衡的机制，为增强癌症免疫治疗创造巨大机会。
