Department of Radiology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
Lung Cancer. 2009 Nov;66(2):211-7. doi: 10.1016/j.lungcan.2009.01.018. Epub 2009 Feb 28.
The aim of the present study was to investigate the difference in doubling time between squamous cell carcinoma (SCC) and adenocarcinoma of solid pulmonary cancer using three-dimensional volumetric software. We included 40 patients with adenocarcinoma and 11 patients with SCC, who underwent CT examinations more than once before surgical treatment. Tumor volumes and doubling times were obtained using three-dimensional volumetric computer software. Statistical analysis was performed using Mann-Whitney's U-test except for negative doubling times (doubling times less than 0 day). Negative doubling time was found in 5 of the 40 adenocarcinomas (13%), but not in any of the patients with SCC. Doubling time was beyond 400 days in 11 of the 40 adenocarcinomas (28%), but was always less than 400 days in SCC. The mean doubling time of SCC was 126+/-58 days (range, 39-221 days; median, 131 days), while that of adenocarcinomas, except for the negative doubling times, was 976+/-3134 days (range, 69-18,678 days; median, 258 days). Doubling time differed significantly between adenocarcinomas and SCC (p<0.01). In conclusion, the median doubling time of SCC lung cancers is less than that of adenocarcinomas, as measured with automated volumetric measurement software.
本研究旨在利用三维容积软件研究实性肺癌中鳞癌（SCC）和腺癌倍增时间的差异。我们纳入了 40 例腺癌患者和 11 例 SCC 患者，这些患者在手术治疗前均进行了多次 CT 检查。使用三维容积计算机软件获得肿瘤体积和倍增时间。除了负倍增时间（倍增时间小于 0 天）外，使用曼-惠特尼 U 检验进行统计分析。在 40 例腺癌中有 5 例（13%）出现负倍增时间，但在任何 SCC 患者中均未出现。在 40 例腺癌中有 11 例（28%）的倍增时间超过 400 天，但 SCC 的倍增时间始终小于 400 天。SCC 的平均倍增时间为 126+/-58 天（范围：39-221 天；中位数：131 天），而腺癌（负倍增时间除外）的平均倍增时间为 976+/-3134 天（范围：69-18678 天；中位数：258 天）。SCC 和腺癌之间的倍增时间差异有统计学意义（p<0.01）。总之，使用自动容积测量软件测量 SCC 肺癌的中位数倍增时间小于腺癌。
