Moscatt Vittoria, Marino Andrea, Ceccarelli Manuela, Cosentino Federica, Zagami Aldo, Celesia Benedetto Maurizio, Nunnari Giuseppe, Cacopardo Bruno
Department of Clinical and Experimental Medicine, Unit of Infectious Diseases, University of Messina, I-98124 Messina, Sicily, Italy.
Department of Biomedical and Biotechnological Sciences, University of Catania, I-95122 Catania, Italy.
Biomed Rep. 2022 Jul 11;17(3):73. doi: 10.3892/br.2022.1556. eCollection 2022 Sep.
is a gram-positive, non-sporulating, facultatively anaerobic bacillus transmitted to humans through ingestion of contaminated foods. Listeriosis represents the third most common cause of death from foodborne illness, with a mortality rate of 20-30%, especially for patients affected by an invasive disease, which typically affects immunocompromised patients, pregnant women, the elderly, and neonates. It causes several clinical syndromes, of which meningitis, meningoencephalitis, and sepsis are the most challenging to deal with. Here, five cases of meningitis/meningoencephalitis affecting two previously healthy immunocompetent and three immunocompromised adult patients treated with ampicillin plus gentamicin are reported. In addition, all the patients described in this report received a low dose of intravenous dexamethasone; four of them made a full recovery. Additionally, a literature search was performed to better explain the appropriate clinical and therapeutic management approaches for these patients, highlighting the value of dexamethasone administration as part of the therapy.
是一种革兰氏阳性、无芽孢、兼性厌氧的杆菌，通过摄入受污染食物传播给人类。李斯特菌病是食源性疾病导致死亡的第三大常见原因，死亡率为20% - 30%，对于受侵袭性疾病影响的患者尤其如此，侵袭性疾病通常影响免疫功能低下的患者、孕妇、老年人和新生儿。它会引发多种临床综合征，其中脑膜炎、脑膜脑炎和败血症最难处理。在此，报告了5例脑膜炎/脑膜脑炎病例，涉及2名先前健康的免疫功能正常的成年患者和3名免疫功能低下的成年患者，他们接受了氨苄西林加庆大霉素治疗。此外，本报告中描述的所有患者均接受了低剂量静脉注射地塞米松；其中4例完全康复。另外，进行了文献检索，以更好地解释这些患者合适的临床和治疗管理方法，强调了地塞米松给药作为治疗一部分的价值。
