Barca Maria Lage, Alnæs Dag, Engedal Knut, Persson Karin, Eldholm Rannveig Sakshaug, Siafarikas Nikias, Selseth Almdahl Ina, Stylianou-Korsnes Maria, Saltvedt Ingvild, Selbæk Geir, Westlye Lars T
Norwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway.
Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway.
Dement Geriatr Cogn Dis Extra. 2022 Jun 23;12(2):107-114. doi: 10.1159/000521114. eCollection 2022 May-Aug.
Findings regarding brain morphometry among patients with dementia and concomitant depressive symptoms have been inconsistent. Thus, the aim of the present study was to test the hypothesis that dementia and concomitant depressive symptoms are associated with structural brain changes in the temporal lobe measured with structural magnetic resonance imaging (MRI).
A sample of 492 patients from Norwegian memory clinics ( = 363) and Old Age Psychiatry services ( = 129) was studied. The assessment included the Cornell Scale for Depression in Dementia (CSDD), Instrumental Activities of Daily Living Scale, Mini Mental State Examination, and MRI of the brain, processed with FreeSurfer to derive ROI measures of cortical thickness, volume, and area using the Desikan-Killiany parcellation, as well as subcortical volumes. Dementia was diagnosed according to ICD-10 research criteria. Correlates of brain morphometry using multiple linear regression were examined.
Higher scores on the CSDD were associated with larger cortical volume (β = 0.125; value = 0.003) and area of the left isthmus of the cingulate gyrus (β = 0.151; value = <0.001) across all patients. Inclusion of an interaction term (dementia × CSDD) revealed a smaller area in the left temporal pole (β = -0.345; value = 0.001) and right-transverse temporal cortex (β = -0.321; value = 0.001) in patients with dementia and depressive symptoms.
DISCUSSION/CONCLUSION: We confirm the previous findings of structural brain changes in temporal regions among patients with dementia and concomitant depressive symptoms. This may contribute to a better understanding of the mechanisms underlying depression in dementia. To the best of our knowledge, this is the largest study conducted on this topic to date.
关于痴呆症患者及伴有抑郁症状者的脑形态测量结果一直不一致。因此，本研究的目的是检验以下假设：痴呆症及伴有抑郁症状与通过结构磁共振成像（MRI）测量的颞叶脑结构变化有关。
对来自挪威记忆诊所（n = 363）和老年精神病科服务机构（n = 129）的492名患者进行了研究。评估包括痴呆症抑郁症状康奈尔量表（CSDD）、日常生活活动能力量表、简易精神状态检查表以及脑部MRI，使用FreeSurfer进行处理，以使用Desikan-Killiany脑图谱得出皮质厚度、体积和面积的ROI测量值，以及皮质下体积。根据ICD-10研究标准诊断痴呆症。使用多元线性回归检查脑形态测量的相关因素。
在所有患者中，CSDD得分越高与更大的皮质体积（β = 0.125；p值 = 0.003）和左侧扣带回峡部面积（β = 0.151；p值 = <0.001）相关。纳入交互项（痴呆症×CSDD）显示，患有痴呆症和抑郁症状的患者左侧颞极（β = -0.345；p值 = 0.001）和右侧颞横回皮质（β = -0.321；p值 = 0.001）的面积较小。
讨论/结论：我们证实了先前关于痴呆症患者及伴有抑郁症状者颞叶脑结构变化的研究结果。这可能有助于更好地理解痴呆症中抑郁的潜在机制。据我们所知，这是迄今为止关于该主题的最大规模研究。
