a Department of Geriatric Medicine, Institute of Clinical Medicine , Oslo University Hospital , Oslo , Norway.
Aging Ment Health. 2014 Jul;18(5):579-87. doi: 10.1080/13607863.2013.827630. Epub 2013 Sep 3.
Depression in dementia is common, but the prevalence rates differ according to the populations studied and which diagnostic tools are being used. The aim of this study is to explore the prevalence of depression among patients referred to a memory clinic or an outpatient clinic as measured by the Cornell Scale of Depression in dementia (CSDD) and to investigate which factors are associated with depression.
The CSDD was completed for 1470 patients on their first visit to a memory clinic or an outpatient clinic. The prevalence of depression using three different cut-off points was calculated. Logistic regression and correlation analyses were performed.
Half of the patients had dementia. The mean CSDD was 6.7 (SD: 5.3) for the whole group, and 50.2% had a score above 5, whereas 37.5% had depression defined as a CSDD score above 7, and 14.1% had a score above 12. The mean scores were higher among those with dementia other than Alzheimer's disease, those with previous depression, and those with greater impairment in the activities of daily living (ADL). In the logistic regression analyses, younger age, ADL dysfunction, and previous depression were significantly associated with higher CSDD scores.
We found that depressive symptoms are common among patients referred for a dementia assessment in specialist health care. The strongest factors associated with depressive symptoms were younger age, ADL impairment, and previous depression.
痴呆患者中抑郁较为常见,但不同研究人群和使用的诊断工具的患病率不同。本研究旨在通过 Cornell 痴呆抑郁量表(CSDD)探讨就诊于记忆门诊或门诊患者中抑郁的患病率,并分析哪些因素与抑郁相关。
对 1470 名首次就诊于记忆门诊或门诊的患者进行 CSDD 评估。计算了使用三种不同截断值的抑郁患病率。进行了逻辑回归和相关性分析。
一半患者患有痴呆。全组 CSDD 平均为 6.7(SD:5.3),50.2%的患者评分高于 5,37.5%的患者被定义为 CSDD 评分高于 7,14.1%的患者评分高于 12。除阿尔茨海默病以外的痴呆、有既往抑郁史和日常生活活动(ADL)受损更严重的患者的平均评分更高。在逻辑回归分析中,年龄较小、ADL 功能障碍和既往抑郁与更高的 CSDD 评分显著相关。
我们发现就诊于专科医疗保健机构进行痴呆评估的患者中抑郁症状较为常见。与抑郁症状最相关的因素是年龄较小、ADL 受损和既往抑郁。