Department of Nuclear Medicine, The First Hospital of Shanxi Medical University, Taiyuan.
Department of Stomatology.
Nucl Med Commun. 2022 Sep 1;43(9):995-1003. doi: 10.1097/MNM.0000000000001605. Epub 2022 Aug 10.
The aim of this study was to evaluate the effect of vitamin E and supragingival scaling with vitamin C on the salivary glands of patients with differentiated thyroid carcinoma after 131I treatment.
A total of 89 prospective patients with differentiated thyroid carcinoma were enrolled and randomly divided into the following groups: vitamin E group (n = 30, group A), vitamin C group (n = 30, group B) and supragingival scaling with vitamin C group (n = 29, group C). Using functional indices (e.g. maximum uptake fraction, uptake index, excretion fraction, secretion time and excretion rate), changes in the salivary gland functions before and a month after 131I treatment were assessed by dynamic imaging of salivary gland.
We compared the before and after 131I therapy results of the three groups. In group A (P < 0.05), the excretion fraction and excretion rate of the left parotid gland were significantly higher, and the uptake index of the bilateral submandibular glands was significantly lower. No significant changes in salivary gland functional parameters were observed in group B (P > 0.05). The uptake index of the bilateral parotid glands and the excretion rate of the left parotid gland were significantly higher in group C (P < 0.05). The degree of serum amylase level reduction decreased significantly in group C (P < 0.05).
Vitamin E showed a protective effect on parotid excretion function in patients with differentiated thyroid carcinoma who underwent 131I treatment. Supragingival scaling may be a promising radiation protector because it is associated with a protective effect on the salivary gland functions.
本研究旨在评估维生素 E 和龈上洁治联合维生素 C 对分化型甲状腺癌患者 131I 治疗后唾液腺的影响。
共纳入 89 例分化型甲状腺癌患者，采用随机数字表法分为维生素 E 组（n=30，A 组）、维生素 C 组（n=30，B 组）和龈上洁治联合维生素 C 组（n=29，C 组）。采用动态唾液腺显像，分别于 131I 治疗前后，通过测定唾液腺功能的各项指标（如最大摄取分数、摄取指数、排泄分数、分泌时间和排泄率）评估患者唾液腺功能的变化。
比较三组患者治疗前后的结果，A 组（P<0.05）左侧腮腺的排泄分数和排泄率明显升高，双侧颌下腺摄取指数明显降低；B 组（P>0.05）唾液腺功能参数无明显变化；C 组（P<0.05）双侧腮腺摄取指数和左侧腮腺排泄率明显升高，血清淀粉酶水平降低程度明显降低（P<0.05）。
维生素 E 对分化型甲状腺癌患者 131I 治疗后腮腺的排泄功能具有保护作用，龈上洁治可能是一种有前途的辐射防护剂，因为它对唾液腺功能具有保护作用。
