Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Taiyuan, .
Fenyang College of Shanxi Medical University, Fenyang, .
Nucl Med Commun. 2024 Apr 1;45(4):312-320. doi: 10.1097/MNM.0000000000001817. Epub 2024 Feb 5.
This study aimed to evaluate the effects of three antioxidants, selenium yeast capsule, vitamin E and vitamin C, alone or in combination, on the salivary glands of patients with differentiated thyroid cancer (DTC) treated with iodine-131 ( 131 I).
A total of 69 postoperative DTC patients were randomly divided into three groups: vitamin E combined with vitamin C group (21 cases); selenium yeast group (23 cases); and selenium yeast combined with vitamin C group (25 cases). Salivary gland functional changes were assessed by salivary gland dynamic imaging functional parameters in the enrolled patients before and 1 month after 131 I treatment.
Comparison of salivary gland function parameters before and after 131 I treatment in the three groups were evaluated. In the vitamin E combined with the vitamin C group, the left parotid gland excretion fraction (EF) value was significantly higher than that before treatment. In the selenium yeast group, the left parotid gland excretion part, bilateral parotid gland excretion ratio (ER), left submandibular gland maximum uptake ratio within 20 min (UR20), and the right submandibular gland ER values were significantly higher than that before treatment, while in the selenium yeast combined with vitamin C group, the bilateral parotid gland EF, bilateral submandibular gland UR20, EF, and left submandibular gland ER values were significantly higher than that before treatment (all P < 0.05).
During high-dose 131 I treatment, vitamin E combined with vitamin C improved the excretory function of parotid glands in DTC patients; selenium supplementation had a protective effect on salivary glands; and the combination of selenium and vitamin C had a better effect.
本研究旨在评估三种抗氧化剂（硒酵母胶囊、维生素 E 和维生素 C）单独或联合应用对接受碘-131（131 I）治疗的分化型甲状腺癌（DTC）患者唾液腺的影响。
将 69 例术后 DTC 患者随机分为三组：维生素 E 联合维生素 C 组（21 例）、硒酵母组（23 例）、硒酵母联合维生素 C 组（25 例）。在 131 I 治疗前和治疗后 1 个月，通过唾液腺动态成像功能参数评估纳入患者的唾液腺功能变化。
评价三组患者治疗前后唾液腺功能参数的变化。在维生素 E 联合维生素 C 组中，左侧腮腺排泄分数（EF）值明显高于治疗前。在硒酵母组中，左侧腮腺排泄部分、双侧腮腺排泄比（ER）、左侧颌下腺 20 分钟内最大摄取率（UR20）和右侧颌下腺 ER 值明显高于治疗前，而在硒酵母联合维生素 C 组中，双侧腮腺 EF、双侧颌下腺 UR20、EF 和左侧颌下腺 ER 值明显高于治疗前（均 P < 0.05）。
在大剂量 131 I 治疗期间，维生素 E 联合维生素 C 可改善 DTC 患者腮腺的排泄功能；补充硒对唾液腺有保护作用；硒与维生素 C 的联合应用效果更好。
