Welliver R C, Ogra P L
J Am Vet Med Assoc. 1978 Sep 1;173(5 Pt 2):560-4.
Evidence suggests that protection against intestinal infections is mediated by an immune system that is unique in many ways. The predominant intestinal immunoglobulin differs in structure, function, and site of origin from those immunoglobulins found in the blood-stream. Cell-mediated intestinal immune responses also may arise separately from those of the rest of the body. Further studies are necessary to characterize the local immune response to many human bacterial, viral, and protozoal pathogens, and to clarify the mechanism of "homing" of immunocompetent cells to the large and small intestine, mammary glands, and other external mucosal surfaces.
有证据表明，针对肠道感染的保护作用是由一个在许多方面都独特的免疫系统介导的。主要的肠道免疫球蛋白在结构、功能和起源部位上与血液中的免疫球蛋白不同。细胞介导的肠道免疫反应也可能与身体其他部位的反应分开产生。有必要进行进一步研究，以表征对许多人类细菌、病毒和原生动物病原体的局部免疫反应，并阐明免疫活性细胞“归巢”至大肠、小肠、乳腺和其他外部黏膜表面的机制。
