Rasmussen K
Dan Med Bull. 1987 Jun;34(3):170-2.
The haemodynamics of fetuses of 15 pregnant women who developed hypertension during the last trimester of pregnancy were investigated before and after antihypertensive treatment using the ultrasound-Doppler method for non-invasive measurements of blood flow, and the results were compared to those from investigations of fetuses from normal pregnancies. In the untreated condition, significant reduction of blood flow was demonstrated in the fetal descending aorta (p less than 0.01) and in the umbilical vein (p less than 0.02). The resistance to flow, expressed as the Pulsatility Index, was significantly elevated (p less than 0.001). A significant correlation was shown between Pulsatility Index and maternal diastolic blood pressure (p less than 0.001) and a significant negative correlation between blood velocity in fetal aorta and maternal diastolic blood pressure (p less than 0.01). Treatment resulted in significant reduction of resistance to flow, which remained normal for the rest of the pregnancy. It is concluded that fetal haemodynamics are affected by maternal hypertension during pregnancy. The results suggest that the fetus also suffers from hypertension. Therapy with oral alpha-methyldopa and labetalol combined with volume expansion with human albumine normalised fetal circulation and kept it normal for the remainder of the pregnancy.
对15名在妊娠晚期出现高血压的孕妇的胎儿进行了血流动力学研究，在降压治疗前后，采用超声多普勒法对血流进行无创测量，并将结果与正常妊娠胎儿的研究结果进行比较。在未治疗的情况下，胎儿降主动脉（p<0.01）和脐静脉（p<0.02）的血流明显减少。以搏动指数表示的血流阻力显著升高（p<0.001）。搏动指数与孕妇舒张压之间存在显著相关性（p<0.001），胎儿主动脉血流速度与孕妇舒张压之间存在显著负相关性（p<0.01）。治疗导致血流阻力显著降低，在妊娠剩余时间内保持正常。结论是胎儿血流动力学受孕期母亲高血压的影响。结果表明胎儿也患有高血压。口服α-甲基多巴和拉贝洛尔联合人白蛋白扩容治疗使胎儿循环正常化，并在妊娠剩余时间内保持正常。
